DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PGSTT
Uniprot ID:
Q7Z5P9
Source protein:
Mucin-19
Source gene:
MUC19
Class:
DEG_SPOP_SBC_1
Location:
6153:6157
E3 ligase:
SPOP
DEGRON score:
0.988
ASA_SCORE:
80.04
COIL:
0.8694
CONS_SCORE:
0.2854
DSS_SCORE:
0.5856
HELIX:
0.0178
FCONS_SCORE:
0.875
RIG_SCORE:
0.6474
Degron related mutations and impact score
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Mutation
Sample
Cancer
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Degron
Degron class
Impact score
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Drug responses associated with MUC19 mutations
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All proteins holding degron of PGSTT
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H5V8
CUB domain-containing protein 1
DEG_SPOP_SBC_1
286:290
PGSTT
SPOP
0.9952
More...
Q99814
Endothelial PAS domain-containing protein 1
DEG_SPOP_SBC_1
465:469
PGSTT
SPOP
0.9562
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P35452
Homeobox protein Hox-D12
DEG_SPOP_SBC_1
147:151
PGSTT
SPOP
0.9966
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Q5T011
KICSTOR complex protein SZT2
DEG_SPOP_SBC_1
537:541
PGSTT
SPOP
0.9681
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Q9ULH0
Kinase D-interacting substrate of 220 kDa
DEG_SPOP_SBC_1
1401:1405
PGSTT
SPOP
0.9945
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
268:272
PGSTT
SPOP
0.9801
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Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
624:628
PGSTT
SPOP
0.9451
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Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
680:684
PGSTT
SPOP
0.8958
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Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
708:712
PGSTT
SPOP
0.5911
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Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
954:958
PGSTT
SPOP
0.8891
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
1066:1070
PGSTT
SPOP
0.9881
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
1232:1236
PGSTT
SPOP
0.8431
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
1512:1516
PGSTT
SPOP
0.9131
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Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
1679:1683
PGSTT
SPOP
0.8675
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Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
1735:1739
PGSTT
SPOP
0.8894
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Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
1763:1767
PGSTT
SPOP
0.765
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Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
2037:2041
PGSTT
SPOP
0.8859
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
2149:2153
PGSTT
SPOP
0.9256
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
2315:2319
PGSTT
SPOP
0.8431
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
2623:2627
PGSTT
SPOP
0.8231
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Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
2789:2793
PGSTT
SPOP
0.9047
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Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
3069:3073
PGSTT
SPOP
0.8831
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Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
3236:3240
PGSTT
SPOP
0.9504
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Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
3292:3296
PGSTT
SPOP
0.8894
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
3594:3598
PGSTT
SPOP
0.8534
More...
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