DegronMD - P35452(HOXD12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P160T	TCGA-86-8054	LUAD	TCGA	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.0833
p.P160T	DO23923	LUAD	ICGC	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.0833
p.G155E	TCGA-BF-A3DL	SKCM	TCGA	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.2222
p.G155E	DO51238	SKCM	ICGC	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.2222
p.Q154H	TCGA-FS-A1ZR	SKCM	TCGA	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.25
p.Q154H	DO37651	SKCM	ICGC	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.25
p.P157S	TCGA-K4-A6FZ	BLCA	TCGA	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.1667
p.P157S	DO44045	BLCA	ICGC	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.1667
p.P157S	DO218560	BRCA	ICGC	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.1667
p.L153I	DO8730	COAD	ICGC	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.2778
p.G161D	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.0556
p.G161D	ACH-000960	Leukemia	CCLE	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.0556
p.G161D	REH	haematopoietic and lymphoid tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.0556
p.A159T	SIDM01017	B-Lymphoblastic Leukemia	GDSC	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.1111
p.A159T	ACH-002255	Lymphoma	CCLE	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.1111
p.A159T	KARPAS-231	haematopoietic and lymphoid tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.1111
p.P160S	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.0833
p.P160S	ACH-001362	Lung Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.0833
p.P160S	NCI-H1770	lung	COSMIC	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.0833
p.L152P	SIDM00537	Colorectal Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.3056
p.L152P	ACH-001345	Colon/Colorectal Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.3056
p.L152P	GP5d	large intestine	COSMIC	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.3056
p.P157L	SIDM00500	Colorectal Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.1667
p.P157L	ACH-000959	Colon/Colorectal Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.1667

Kaplan plot for HOXD12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HOXD12

UniProt ID: P35452

Entrez ID: 3238

Protein name: Homeobox protein Hox-D12 (Homeobox protein Hox-4H)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HOXD12 in