DegronMD

Uniprot ID: P35452

Source protein: Homeobox protein Hox-D12

Source gene: HOXD12

Class: DEG_SPOP_SBC_1

Location: 147:151

E3 ligase: SPOP

DEGRON score: 0.9966

ASA_SCORE: 66.16

COIL: 0.8442

CONS_SCORE: 0.3655

DSS_SCORE: 0.3517

HELIX: 0.1292

FCONS_SCORE: 0.8602

RIG_SCORE: 0.7103

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P160T	TCGA-86-8054	LUAD	TCGA	PGSTT	DEG_SPOP_SBC_1	0.0833
p.P160T	DO23923	LUAD	ICGC	PGSTT	DEG_SPOP_SBC_1	0.0833
p.G155E	TCGA-BF-A3DL	SKCM	TCGA	PGSTT	DEG_SPOP_SBC_1	0.2222
p.G155E	DO51238	SKCM	ICGC	PGSTT	DEG_SPOP_SBC_1	0.2222
p.Q154H	TCGA-FS-A1ZR	SKCM	TCGA	PGSTT	DEG_SPOP_SBC_1	0.25
p.Q154H	DO37651	SKCM	ICGC	PGSTT	DEG_SPOP_SBC_1	0.25
p.P157S	TCGA-K4-A6FZ	BLCA	TCGA	PGSTT	DEG_SPOP_SBC_1	0.1667
p.P157S	DO44045	BLCA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.1667
p.P157S	DO218560	BRCA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.1667
p.L153I	DO8730	COAD	ICGC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.G161D	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.G161D	ACH-000960	Leukemia	CCLE	PGSTT	DEG_SPOP_SBC_1	0.0556
p.G161D	REH	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.A159T	SIDM01017	B-Lymphoblastic Leukemia	GDSC	PGSTT	DEG_SPOP_SBC_1	0.1111
p.A159T	ACH-002255	Lymphoma	CCLE	PGSTT	DEG_SPOP_SBC_1	0.1111
p.A159T	KARPAS-231	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.1111
p.P160S	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.0833
p.P160S	ACH-001362	Lung Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	0.0833
p.P160S	NCI-H1770	lung	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.0833
p.L152P	SIDM00537	Colorectal Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.L152P	ACH-001345	Colon/Colorectal Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	0.3056
p.L152P	GP5d	large_intestine	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.P157L	SIDM00500	Colorectal Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.1667
p.P157L	ACH-000959	Colon/Colorectal Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35452	Homeobox protein Hox-D12	DEG_SPOP_SBC_1	147:151	PGSTT	SPOP	0.9966	More...
Q13263	Transcription intermediary factor 1-beta	DEG_SPOP_SBC_1	510:514	PGSTT	SPOP	0.9961	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	537:541	PGSTT	SPOP	0.9681	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6153:6157	PGSTT	SPOP	0.988	More...
Q99814	Endothelial PAS domain-containing protein 1	DEG_SPOP_SBC_1	465:469	PGSTT	SPOP	0.9562	More...
Q9H5V8	CUB domain-containing protein 1	DEG_SPOP_SBC_1	286:290	PGSTT	SPOP	0.9952	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	268:272	PGSTT	SPOP	0.9801	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	624:628	PGSTT	SPOP	0.9451	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	680:684	PGSTT	SPOP	0.8958	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	708:712	PGSTT	SPOP	0.5911	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	954:958	PGSTT	SPOP	0.8891	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1066:1070	PGSTT	SPOP	0.9881	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1232:1236	PGSTT	SPOP	0.8431	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1512:1516	PGSTT	SPOP	0.9131	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1679:1683	PGSTT	SPOP	0.8675	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1735:1739	PGSTT	SPOP	0.8894	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1763:1767	PGSTT	SPOP	0.765	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2037:2041	PGSTT	SPOP	0.8859	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2149:2153	PGSTT	SPOP	0.9256	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2315:2319	PGSTT	SPOP	0.8431	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2623:2627	PGSTT	SPOP	0.8231	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2789:2793	PGSTT	SPOP	0.9047	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3069:3073	PGSTT	SPOP	0.8831	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3236:3240	PGSTT	SPOP	0.9504	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3292:3296	PGSTT	SPOP	0.8894	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3594:3598	PGSTT	SPOP	0.8534	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3706:3710	PGSTT	SPOP	0.9783	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3872:3876	PGSTT	SPOP	0.9192	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4152:4156	PGSTT	SPOP	0.876	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4319:4323	PGSTT	SPOP	0.9707	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4403:4407	PGSTT	SPOP	0.765	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4677:4681	PGSTT	SPOP	0.8675	More...
Q9ULH0	Kinase D-interacting substrate of 220 kDa	DEG_SPOP_SBC_1	1401:1405	PGSTT	SPOP	0.9945	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	232:236	PGSTT	SPOP	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGSTT

Degron related mutations and impact score

Drug responses associated with HOXD12 mutations

All proteins holding degron of PGSTT