DegronMD

Uniprot ID: Q5T011

Source protein: KICSTOR complex protein SZT2

Source gene: SZT2

Class: DEG_SPOP_SBC_1

Location: 537:541

E3 ligase: SPOP

DEGRON score: 0.9681

ASA_SCORE: 77.24

COIL: 0.943

CONS_SCORE: 0.3009

DSS_SCORE: 0.3448

HELIX: 0.0144

FCONS_SCORE: 1.009

RIG_SCORE: 0.6858

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L544V	TCGA-62-8399	LUAD	TCGA	PGSTT	DEG_SPOP_SBC_1	0.25
p.L544V	DO24606	LUAD	ICGC	PGSTT	DEG_SPOP_SBC_1	0.25
p.S539Y	TCGA-85-A4JC	LUSC	TCGA	PGSTT	DEG_SPOP_SBC_1	0.712
p.S539Y	DO45429	LUSC	ICGC	PGSTT	DEG_SPOP_SBC_1	0.712
p.P542L	TCGA-EB-A3Y7	SKCM	TCGA	PGSTT	DEG_SPOP_SBC_1	0.3056
p.P542L	DO37499	SKCM	ICGC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.G538C	TCGA-EE-A3AA	SKCM	TCGA	PGSTT	DEG_SPOP_SBC_1	0.6489
p.G538C	DO37571	SKCM	ICGC	PGSTT	DEG_SPOP_SBC_1	0.6489
p.P536S	TCGA-EO-A22U	UCEC	TCGA	PGSTT	DEG_SPOP_SBC_1	0.3056
p.P536S	DO43755	UCEC	ICGC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.H533R	DO222769	COCA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.2222
p.R549H	DO234407	ESAD	ICGC	PGSTT	DEG_SPOP_SBC_1	0.1111
p.A528V	DO22237	LGG	ICGC	PGSTT	DEG_SPOP_SBC_1	0.0833
p.S544I	DO26728	LUSC	ICGC	PGSTT	DEG_SPOP_SBC_1	0.25
p.I536T	DO42713	UCEC	ICGC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.G550D	DO229542	UTCA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.0833
p.L546P	SIDM00517	Head and Neck Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35452	Homeobox protein Hox-D12	DEG_SPOP_SBC_1	147:151	PGSTT	SPOP	0.9966	More...
Q13263	Transcription intermediary factor 1-beta	DEG_SPOP_SBC_1	510:514	PGSTT	SPOP	0.9961	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	537:541	PGSTT	SPOP	0.9681	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6153:6157	PGSTT	SPOP	0.988	More...
Q99814	Endothelial PAS domain-containing protein 1	DEG_SPOP_SBC_1	465:469	PGSTT	SPOP	0.9562	More...
Q9H5V8	CUB domain-containing protein 1	DEG_SPOP_SBC_1	286:290	PGSTT	SPOP	0.9952	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	268:272	PGSTT	SPOP	0.9801	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	624:628	PGSTT	SPOP	0.9451	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	680:684	PGSTT	SPOP	0.8958	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	708:712	PGSTT	SPOP	0.5911	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	954:958	PGSTT	SPOP	0.8891	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1066:1070	PGSTT	SPOP	0.9881	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1232:1236	PGSTT	SPOP	0.8431	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1512:1516	PGSTT	SPOP	0.9131	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1679:1683	PGSTT	SPOP	0.8675	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1735:1739	PGSTT	SPOP	0.8894	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1763:1767	PGSTT	SPOP	0.765	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2037:2041	PGSTT	SPOP	0.8859	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2149:2153	PGSTT	SPOP	0.9256	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2315:2319	PGSTT	SPOP	0.8431	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2623:2627	PGSTT	SPOP	0.8231	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2789:2793	PGSTT	SPOP	0.9047	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3069:3073	PGSTT	SPOP	0.8831	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3236:3240	PGSTT	SPOP	0.9504	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3292:3296	PGSTT	SPOP	0.8894	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3594:3598	PGSTT	SPOP	0.8534	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3706:3710	PGSTT	SPOP	0.9783	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3872:3876	PGSTT	SPOP	0.9192	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4152:4156	PGSTT	SPOP	0.876	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4319:4323	PGSTT	SPOP	0.9707	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4403:4407	PGSTT	SPOP	0.765	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4677:4681	PGSTT	SPOP	0.8675	More...
Q9ULH0	Kinase D-interacting substrate of 220 kDa	DEG_SPOP_SBC_1	1401:1405	PGSTT	SPOP	0.9945	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	232:236	PGSTT	SPOP	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGSTT

Degron related mutations and impact score

Drug responses associated with SZT2 mutations

All proteins holding degron of PGSTT