DegronMD

Uniprot ID: Q13263

Source protein: Transcription intermediary factor 1-beta

Source gene: TRIM28

Class: DEG_SPOP_SBC_1

Location: 510:514

E3 ligase: SPOP

DEGRON score: 0.9961

ASA_SCORE: 70.62

COIL: 0.9042

CONS_SCORE: 0.2566

DSS_SCORE: 0.3121

HELIX: 0.0372

FCONS_SCORE: 0.8837

RIG_SCORE: 0.7306

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V508D	TCGA-2X-A9D6	TGCT	TCGA	PGSTT	DEG_SPOP_SBC_1	0.2778
p.V508L	TCGA-73-4662	LUAD	TCGA	PGSTT	DEG_SPOP_SBC_1	0.2778
p.V508L	DO24790	LUAD	ICGC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.E501K	DO457	BLCA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.5278
p.R524C	DO230346	COCA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.T517S	DO228787	GACA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.6944
p.P503A	DO27349	LUSC	ICGC	PGSTT	DEG_SPOP_SBC_1	0.1389
p.D516E	DO38663	STAD	ICGC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.S516G	DO41871	UCEC	ICGC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.E501D	DO42673	UCEC	ICGC	PGSTT	DEG_SPOP_SBC_1	0.5278
p.V505I	SIDM00889	Cervical Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.1944
p.V505I	ACH-001333	Cervical Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	0.1944
p.V505I	C-33-A	cervix	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.1944
p.T514N	SIDM00282	Colorectal Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.8166
p.T514N	ACH-000998	Colon/Colorectal Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	0.8166
p.T514N	CW-2	large_intestine	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.8166
p.Q502H	SIDM01051	Ovarian Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.1111
p.Q502H	ACH-000936	Ovarian Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	0.1111
p.Q502H	EFO-27	ovary	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.1111
p.E515K	SIDM00217	Colorectal Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.E515K	ACH-000999	Colon/Colorectal Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	0.3056
p.E515K	SNU-1040	large_intestine	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.S519L	MDA-MB-415	breast	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.1944
p.S516N	DU-145	prostate	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35452	Homeobox protein Hox-D12	DEG_SPOP_SBC_1	147:151	PGSTT	SPOP	0.9966	More...
Q13263	Transcription intermediary factor 1-beta	DEG_SPOP_SBC_1	510:514	PGSTT	SPOP	0.9961	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	537:541	PGSTT	SPOP	0.9681	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6153:6157	PGSTT	SPOP	0.988	More...
Q99814	Endothelial PAS domain-containing protein 1	DEG_SPOP_SBC_1	465:469	PGSTT	SPOP	0.9562	More...
Q9H5V8	CUB domain-containing protein 1	DEG_SPOP_SBC_1	286:290	PGSTT	SPOP	0.9952	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	268:272	PGSTT	SPOP	0.9801	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	624:628	PGSTT	SPOP	0.9451	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	680:684	PGSTT	SPOP	0.8958	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	708:712	PGSTT	SPOP	0.5911	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	954:958	PGSTT	SPOP	0.8891	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1066:1070	PGSTT	SPOP	0.9881	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1232:1236	PGSTT	SPOP	0.8431	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1512:1516	PGSTT	SPOP	0.9131	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1679:1683	PGSTT	SPOP	0.8675	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1735:1739	PGSTT	SPOP	0.8894	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1763:1767	PGSTT	SPOP	0.765	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2037:2041	PGSTT	SPOP	0.8859	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2149:2153	PGSTT	SPOP	0.9256	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2315:2319	PGSTT	SPOP	0.8431	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2623:2627	PGSTT	SPOP	0.8231	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2789:2793	PGSTT	SPOP	0.9047	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3069:3073	PGSTT	SPOP	0.8831	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3236:3240	PGSTT	SPOP	0.9504	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3292:3296	PGSTT	SPOP	0.8894	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3594:3598	PGSTT	SPOP	0.8534	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3706:3710	PGSTT	SPOP	0.9783	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3872:3876	PGSTT	SPOP	0.9192	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4152:4156	PGSTT	SPOP	0.876	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4319:4323	PGSTT	SPOP	0.9707	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4403:4407	PGSTT	SPOP	0.765	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4677:4681	PGSTT	SPOP	0.8675	More...
Q9ULH0	Kinase D-interacting substrate of 220 kDa	DEG_SPOP_SBC_1	1401:1405	PGSTT	SPOP	0.9945	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	232:236	PGSTT	SPOP	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGSTT

Degron related mutations and impact score

Drug responses associated with TRIM28 mutations

All proteins holding degron of PGSTT