DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SPOP_SBC_1

Location: 3236:3240

E3 ligase: SPOP

DEGRON score: 0.9504

ASA_SCORE: 75.86

COIL: 0.7354

CONS_SCORE: 0

DSS_SCORE: 0.6558

HELIX: 0.0116

FCONS_SCORE: 0

RIG_SCORE: 0.6585

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K3247I	DO224689	COCA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.25
p.K3247I	DO228005	LAML	ICGC	PGSTT	DEG_SPOP_SBC_1	0.25
p.K3247I	DO228008	LAML	ICGC	PGSTT	DEG_SPOP_SBC_1	0.25
p.K3247I	DO51028	LAML	ICGC	PGSTT	DEG_SPOP_SBC_1	0.25
p.K3247I	DO228985	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.25
p.K3247I	DO224541	LUSC	ICGC	PGSTT	DEG_SPOP_SBC_1	0.25
p.K3247I	DO52342	LUSC	ICGC	PGSTT	DEG_SPOP_SBC_1	0.25
p.K3247I	DO52346	LUSC	ICGC	PGSTT	DEG_SPOP_SBC_1	0.25
p.T3241A	DO36556	READ	ICGC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.G3241R	SIDM00545	Melanoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.G3241R	Mewo	skin	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.S3226L	SIDM00222	Mesothelioma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.S3226L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.S3226L	SIDM00103	Mesothelioma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.S3226L	SIDM00898	Breast Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.S3226L	SIDM00438	B-Lymphoblastic Leukemia	GDSC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.S3226L	MPP-89	pleura	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.S3226L	AU565	breast	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.S3226L	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.S3226L	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.S3226L	H2373	pleura	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.P3233H	SIDM00082	Melanoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.25
p.P3233H	SK-MEL-2	skin	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.25
p.R3239C	SIDM00087	Plasma Cell Myeloma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.8301
p.R3239C	SIDM00694	Other Solid Cancers	GDSC	PGSTT	DEG_SPOP_SBC_1	0.8301
p.R3239C	SIDM00710	Small Cell Lung Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.8301
p.R3239C	HUTU-80	small_intestine	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.8301
p.R3239C	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.8301
p.R3239C	NCI-H2081	lung	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.8301
p.T3237A	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.7139
p.T3237A	NCI-H2172	lung	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.7139
p.P3236H	ACH-000844	Lung Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	0.7694
p.T3244A	EW-1	bone	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2222
p.T3244A	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2222
p.T3244A	CADO-ES1	bone	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2222
p.T3244A	NUGC-4	stomach	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2222
p.T3244A	HOS	bone	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2222
p.A3234D	H3255	lung	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.S3232P	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2222
p.H3228Q	DMS-79	lung	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGSTT

Degron related mutations and impact score

Drug responses associated with MUC12 mutations

All proteins holding degron of PGSTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35452	Homeobox protein Hox-D12	DEG_SPOP_SBC_1	147:151	PGSTT	SPOP	0.9966	More...
Q13263	Transcription intermediary factor 1-beta	DEG_SPOP_SBC_1	510:514	PGSTT	SPOP	0.9961	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	537:541	PGSTT	SPOP	0.9681	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6153:6157	PGSTT	SPOP	0.988	More...
Q99814	Endothelial PAS domain-containing protein 1	DEG_SPOP_SBC_1	465:469	PGSTT	SPOP	0.9562	More...
Q9H5V8	CUB domain-containing protein 1	DEG_SPOP_SBC_1	286:290	PGSTT	SPOP	0.9952	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	268:272	PGSTT	SPOP	0.9801	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	624:628	PGSTT	SPOP	0.9451	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	680:684	PGSTT	SPOP	0.8958	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	708:712	PGSTT	SPOP	0.5911	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	954:958	PGSTT	SPOP	0.8891	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1066:1070	PGSTT	SPOP	0.9881	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1232:1236	PGSTT	SPOP	0.8431	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1512:1516	PGSTT	SPOP	0.9131	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1679:1683	PGSTT	SPOP	0.8675	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1735:1739	PGSTT	SPOP	0.8894	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1763:1767	PGSTT	SPOP	0.765	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2037:2041	PGSTT	SPOP	0.8859	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2149:2153	PGSTT	SPOP	0.9256	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2315:2319	PGSTT	SPOP	0.8431	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2623:2627	PGSTT	SPOP	0.8231	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2789:2793	PGSTT	SPOP	0.9047	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3069:3073	PGSTT	SPOP	0.8831	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3236:3240	PGSTT	SPOP	0.9504	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3292:3296	PGSTT	SPOP	0.8894	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3594:3598	PGSTT	SPOP	0.8534	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3706:3710	PGSTT	SPOP	0.9783	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3872:3876	PGSTT	SPOP	0.9192	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4152:4156	PGSTT	SPOP	0.876	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4319:4323	PGSTT	SPOP	0.9707	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4403:4407	PGSTT	SPOP	0.765	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4677:4681	PGSTT	SPOP	0.8675	More...
Q9ULH0	Kinase D-interacting substrate of 220 kDa	DEG_SPOP_SBC_1	1401:1405	PGSTT	SPOP	0.9945	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	232:236	PGSTT	SPOP	0.9955	More...