DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SPOP_SBC_1

Location: 680:684

E3 ligase: SPOP

DEGRON score: 0.8958

ASA_SCORE: 80.72

COIL: 0.8306

CONS_SCORE: 0

DSS_SCORE: 0.7615

HELIX: 0.0124

FCONS_SCORE: 0

RIG_SCORE: 0.6036

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P680H	TOV-21G	ovary	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.7694
p.P680H	SNU-175	large_intestine	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.7694
p.P680R	SUP-B15	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.7512
p.T684A	ACH-000930	Breast Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	0.7139
p.T684A	HCC1569	breast	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.7139
p.T684I	DO222837	MELA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.7078
p.T684N	EN	endometrium	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.7055
p.G681D	SNU-1040	large_intestine	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.6087
p.F679Y	ACH-000999	Colon/Colorectal Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	0.3056
p.F679L	U-CH2	bone	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.L688V	DO228967	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.2222
p.L688V	DO229056	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.2222
p.E691Q	ACH-000211	Brain Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	0.1389
p.E691Q	Daoy	central_nervous_system	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.1389
p.P693L	NCI-H630	large_intestine	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.0833
p.R670Q	U-CH2	bone	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.0556

Showing 1 to 16 of 16 entries

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Drug responses associated with MUC12 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PGSTT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H5V8	CUB domain-containing protein 1	DEG_SPOP_SBC_1	286:290	PGSTT	SPOP	0.9952	More...
Q99814	Endothelial PAS domain-containing protein 1	DEG_SPOP_SBC_1	465:469	PGSTT	SPOP	0.9562	More...
P35452	Homeobox protein Hox-D12	DEG_SPOP_SBC_1	147:151	PGSTT	SPOP	0.9966	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	537:541	PGSTT	SPOP	0.9681	More...
Q9ULH0	Kinase D-interacting substrate of 220 kDa	DEG_SPOP_SBC_1	1401:1405	PGSTT	SPOP	0.9945	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	268:272	PGSTT	SPOP	0.9801	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	624:628	PGSTT	SPOP	0.9451	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	680:684	PGSTT	SPOP	0.8958	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	708:712	PGSTT	SPOP	0.5911	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	954:958	PGSTT	SPOP	0.8891	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1066:1070	PGSTT	SPOP	0.9881	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1232:1236	PGSTT	SPOP	0.8431	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1512:1516	PGSTT	SPOP	0.9131	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1679:1683	PGSTT	SPOP	0.8675	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1735:1739	PGSTT	SPOP	0.8894	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1763:1767	PGSTT	SPOP	0.765	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2037:2041	PGSTT	SPOP	0.8859	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2149:2153	PGSTT	SPOP	0.9256	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2315:2319	PGSTT	SPOP	0.8431	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2623:2627	PGSTT	SPOP	0.8231	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2789:2793	PGSTT	SPOP	0.9047	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3069:3073	PGSTT	SPOP	0.8831	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3236:3240	PGSTT	SPOP	0.9504	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3292:3296	PGSTT	SPOP	0.8894	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3594:3598	PGSTT	SPOP	0.8534	More...

Showing 1 to 25 of 34 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGSTT

Degron related mutations and impact score

Drug responses associated with MUC12 mutations

All proteins holding degron of PGSTT