DegronMD - Q9H5V8(CDCP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P716A	TCGA-23-1118	OV	TCGA	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation rewiring degron network	0.1389
p.P716A	DO30220	OV	ICGC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation rewiring degron network	0.1389
p.L297P	TCGA-BR-8676	STAD	TCGA	PGSTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.1389
p.L297P	DO47865	STAD	ICGC	PGSTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.1389
p.N699S	TCGA-EE-A2GP	SKCM	TCGA	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation rewiring degron network	0.1944
p.N699S	DO37422	SKCM	ICGC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation rewiring degron network	0.1944
p.R276K	TCGA-FR-A3R1	SKCM	TCGA	PGSTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0556
p.R276K	DO37991	SKCM	ICGC	PGSTT	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0556
p.D709G	DO229010	COCA	ICGC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation altering degron motif	0.7198
p.D709G	DO229013	COCA	ICGC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation altering degron motif	0.7198
p.D709G	DO229016	COCA	ICGC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation altering degron motif	0.7198
p.D709G	DO229003	COCA	ICGC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation altering degron motif	0.7198
p.D709G	DO229005	COCA	ICGC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation altering degron motif	0.7198
p.E714D	DO233270	GACA	ICGC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation rewiring degron network	0.1944
p.N710K	DO228924	LICA	ICGC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation rewiring degron network	0.3056
p.K695E	DO228371	MALY	ICGC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation substituting flanking lysine	0.1944
p.K695E	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation substituting flanking lysine	0.1944
p.K695E	KARPAS-422	haematopoietic and lymphoid tissue	COSMIC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation substituting flanking lysine	0.1944
p.E714K	DO229456	SKCA	ICGC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation rewiring degron network	0.1944
p.A703T	SIDM00216	Colorectal Carcinoma	GDSC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation rewiring degron network	0.3056
p.A703T	SIDM00018	Acute Myeloid Leukemia	GDSC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation rewiring degron network	0.3056
p.A703T	SIDM01569	Hepatocellular Carcinoma	GDSC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation rewiring degron network	0.3056
p.A703T	SNU-175	large intestine	COSMIC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation rewiring degron network	0.3056
p.A703T	KO52	haematopoietic and lymphoid tissue	COSMIC	VGIYND	LIG_APCC_ABBA_1	704:709	Mutation rewiring degron network	0.3056
p.P286L	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.7582
p.P286L	ACH-000916	Lung Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.7582
p.P286L	NCI-H1573	lung	COSMIC	PGSTT	DEG_SPOP_SBC_1	286:290	Mutation altering degron motif	0.7582

Kaplan plot for CDCP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDCP1

UniProt ID: Q9H5V8

Entrez ID: 64866

Protein name: CUB domain-containing protein 1 (Membrane glycoprotein gp140) (Subtractive immunization M plus HEp3-associated 135 kDa protein) (SIMA135) (Transmembrane and associated with src kinases) (CD antigen CD318)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDCP1 in