DegronMD

Uniprot ID: Q9H5V8

Source protein: CUB domain-containing protein 1

Source gene: CDCP1

Class: LIG_APCC_ABBA_1

Location: 704:709

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8959

ASA_SCORE: 51.4333

COIL: 0.5737

CONS_SCORE: 0.7588

DSS_SCORE: 0.461

HELIX: 0.0277

FCONS_SCORE: 1.284

RIG_SCORE: 0.7852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P716A	TCGA-23-1118	OV	TCGA	VGIYND	LIG_APCC_ABBA_1	0.1389
p.P716A	DO30220	OV	ICGC	VGIYND	LIG_APCC_ABBA_1	0.1389
p.N699S	TCGA-EE-A2GP	SKCM	TCGA	VGIYND	LIG_APCC_ABBA_1	0.1944
p.N699S	DO37422	SKCM	ICGC	VGIYND	LIG_APCC_ABBA_1	0.1944
p.D709G	DO229010	COCA	ICGC	VGIYND	LIG_APCC_ABBA_1	0.7198
p.D709G	DO229013	COCA	ICGC	VGIYND	LIG_APCC_ABBA_1	0.7198
p.D709G	DO229016	COCA	ICGC	VGIYND	LIG_APCC_ABBA_1	0.7198
p.D709G	DO229003	COCA	ICGC	VGIYND	LIG_APCC_ABBA_1	0.7198
p.D709G	DO229005	COCA	ICGC	VGIYND	LIG_APCC_ABBA_1	0.7198
p.E714D	DO233270	GACA	ICGC	VGIYND	LIG_APCC_ABBA_1	0.1944
p.N710K	DO228924	LICA	ICGC	VGIYND	LIG_APCC_ABBA_1	0.3056
p.K695E	DO228371	MALY	ICGC	VGIYND	LIG_APCC_ABBA_1	0.1944
p.K695E	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	VGIYND	LIG_APCC_ABBA_1	0.1944
p.K695E	KARPAS-422	haematopoietic_and_lymphoid_tissue	COSMIC	VGIYND	LIG_APCC_ABBA_1	0.1944
p.E714K	DO229456	SKCA	ICGC	VGIYND	LIG_APCC_ABBA_1	0.1944
p.A703T	SIDM00216	Colorectal Carcinoma	GDSC	VGIYND	LIG_APCC_ABBA_1	0.3056
p.A703T	SIDM00018	Acute Myeloid Leukemia	GDSC	VGIYND	LIG_APCC_ABBA_1	0.3056
p.A703T	SIDM01569	Hepatocellular Carcinoma	GDSC	VGIYND	LIG_APCC_ABBA_1	0.3056
p.A703T	SNU-175	large_intestine	COSMIC	VGIYND	LIG_APCC_ABBA_1	0.3056
p.A703T	KO52	haematopoietic_and_lymphoid_tissue	COSMIC	VGIYND	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H5V8	CUB domain-containing protein 1	LIG_APCC_ABBA_1	704:709	VGIYND	APC,CDC20,FZR1	0.8959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons