DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SPOP_SBC_1

Location: 624:628

E3 ligase: SPOP

DEGRON score: 0.9451

ASA_SCORE: 77.86

COIL: 0.8676

CONS_SCORE: 0

DSS_SCORE: 0.6861

HELIX: 0.011

FCONS_SCORE: 0

RIG_SCORE: 0.6163

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G625D	DO229013	COCA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.6087
p.G625D	ACH-001786	Colon/Colorectal Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	0.6087
p.G625D	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.6087
p.G625D	LU-65	lung	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.6087
p.G625D	NCC010	kidney	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.6087
p.G625D	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.6087
p.G625C	DO229026	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.6489
p.K629T	DO229030	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.K629T	DO229052	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.K629T	DO229056	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.S614I	DO229037	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.S636F	DO220913	MELA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.1111
p.S636F	DO35721	PBCA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.1111
p.E619K	DO222395	MELA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.1944
p.A622T	SIDM00411	Pancreatic Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.A622T	SIDM00599	Osteosarcoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.A622T	YAPC	pancreas	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.A622T	HuO9	bone	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.R627H	SIDM00521	Small Cell Lung Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.8244
p.R627H	COR-L95	lung	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.8244
p.S614L	SIDM01133	Other Solid Cancers	GDSC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.S614L	NCI-H835	lung	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.T633R	SIDM00233	T-Lymphoblastic Leukemia	GDSC	PGSTT	DEG_SPOP_SBC_1	0.1944
p.T633R	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.1944
p.S626I	ACH-000364	Primary	CCLE	PGSTT	DEG_SPOP_SBC_1	0.7341
p.S626I	U-2-OS	bone	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.7341
p.T638I	ACH-000997	Colon/Colorectal Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	0.0556
p.T638I	HCT-15	large_intestine	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.A622V	ACH-000999	Colon/Colorectal Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	0.2778
p.A622V	SNU-1040	large_intestine	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.M618V	ACH-001656	Leukemia	CCLE	PGSTT	DEG_SPOP_SBC_1	0.1667
p.M618V	KMRC-20	kidney	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.1667
p.K629N	ACH-001669	Leukemia	CCLE	PGSTT	DEG_SPOP_SBC_1	0.3056
p.K629N	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.P624R	ACH-001675	Head and Neck Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	0.7512
p.P624S	CHL-1	skin	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.6752
p.L623S	HSC-39	stomach	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.G625S	SHP-77	lung	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.5882

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGSTT

Degron related mutations and impact score

Drug responses associated with MUC12 mutations

All proteins holding degron of PGSTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35452	Homeobox protein Hox-D12	DEG_SPOP_SBC_1	147:151	PGSTT	SPOP	0.9966	More...
Q13263	Transcription intermediary factor 1-beta	DEG_SPOP_SBC_1	510:514	PGSTT	SPOP	0.9961	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	537:541	PGSTT	SPOP	0.9681	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6153:6157	PGSTT	SPOP	0.988	More...
Q99814	Endothelial PAS domain-containing protein 1	DEG_SPOP_SBC_1	465:469	PGSTT	SPOP	0.9562	More...
Q9H5V8	CUB domain-containing protein 1	DEG_SPOP_SBC_1	286:290	PGSTT	SPOP	0.9952	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	268:272	PGSTT	SPOP	0.9801	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	624:628	PGSTT	SPOP	0.9451	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	680:684	PGSTT	SPOP	0.8958	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	708:712	PGSTT	SPOP	0.5911	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	954:958	PGSTT	SPOP	0.8891	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1066:1070	PGSTT	SPOP	0.9881	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1232:1236	PGSTT	SPOP	0.8431	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1512:1516	PGSTT	SPOP	0.9131	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1679:1683	PGSTT	SPOP	0.8675	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1735:1739	PGSTT	SPOP	0.8894	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1763:1767	PGSTT	SPOP	0.765	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2037:2041	PGSTT	SPOP	0.8859	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2149:2153	PGSTT	SPOP	0.9256	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2315:2319	PGSTT	SPOP	0.8431	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2623:2627	PGSTT	SPOP	0.8231	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2789:2793	PGSTT	SPOP	0.9047	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3069:3073	PGSTT	SPOP	0.8831	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3236:3240	PGSTT	SPOP	0.9504	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3292:3296	PGSTT	SPOP	0.8894	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3594:3598	PGSTT	SPOP	0.8534	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3706:3710	PGSTT	SPOP	0.9783	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3872:3876	PGSTT	SPOP	0.9192	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4152:4156	PGSTT	SPOP	0.876	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4319:4323	PGSTT	SPOP	0.9707	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4403:4407	PGSTT	SPOP	0.765	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4677:4681	PGSTT	SPOP	0.8675	More...
Q9ULH0	Kinase D-interacting substrate of 220 kDa	DEG_SPOP_SBC_1	1401:1405	PGSTT	SPOP	0.9945	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	232:236	PGSTT	SPOP	0.9955	More...