DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PPTPAAT
Uniprot ID:
Q9UPQ9
Source protein:
Trinucleotide repeat-containing gene 6B protein
Source gene:
TNRC6B
Class:
DEG_SCF_FBW7_1
Location:
1732:1738
E3 ligase:
FBXW7
DEGRON score:
0.9657
ASA_SCORE:
89.7286
COIL:
0.963
CONS_SCORE:
0.3738
DSS_SCORE:
0.6068
HELIX:
0.022
FCONS_SCORE:
0.9151
RIG_SCORE:
0.6358
Degron related mutations and impact score
Show
10
25
50
100
entries
Search:
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P1735H
TCGA-EB-A24D
SKCM
TCGA
PPTPAAT
DEG_SCF_FBW7_1
0.7694
p.A1737V
SIDM00416
B-Cell Non-Hodgkin's Lymphoma
GDSC
PPTPAAT
DEG_SCF_FBW7_1
0.5825
p.A1737V
VAL
haematopoietic_and_lymphoid_tissue
COSMIC
PPTPAAT
DEG_SCF_FBW7_1
0.5825
p.P1739L
TCGA-FS-A1ZK
SKCM
TCGA
PPTPAAT
DEG_SCF_FBW7_1
0.3056
p.P1739L
DO37474
SKCM
ICGC
PPTPAAT
DEG_SCF_FBW7_1
0.3056
p.S1740G
TCGA-XP-A8T6
ESCA
TCGA
PPTPAAT
DEG_SCF_FBW7_1
0.2778
p.A1741V
TCGA-BR-4361
STAD
TCGA
PPTPAAT
DEG_SCF_FBW7_1
0.25
p.A1741V
DO38887
STAD
ICGC
PPTPAAT
DEG_SCF_FBW7_1
0.25
p.Q1729H
TCGA-EO-A3B0
UCEC
TCGA
PPTPAAT
DEG_SCF_FBW7_1
0.25
p.L1727V
TCGA-60-2698
LUSC
TCGA
PPTPAAT
DEG_SCF_FBW7_1
0.1944
p.L1727V
DO26469
LUSC
ICGC
PPTPAAT
DEG_SCF_FBW7_1
0.1944
p.A1743V
TCGA-AJ-A23O
UCEC
TCGA
PPTPAAT
DEG_SCF_FBW7_1
0.1944
p.R1725G
TCGA-DA-A1I1
SKCM
TCGA
PPTPAAT
DEG_SCF_FBW7_1
0.1389
p.R1725G
DO37966
SKCM
ICGC
PPTPAAT
DEG_SCF_FBW7_1
0.1389
p.R1725L
DO228818
MALY
ICGC
PPTPAAT
DEG_SCF_FBW7_1
0.1389
p.R1725H
SIDM00216
Colorectal Carcinoma
GDSC
PPTPAAT
DEG_SCF_FBW7_1
0.1389
p.R1725H
SNU-175
large_intestine
COSMIC
PPTPAAT
DEG_SCF_FBW7_1
0.1389
p.V1723A
TCGA-AP-A051
UCEC
TCGA
PPTPAAT
DEG_SCF_FBW7_1
0.0833
p.V1723A
DO42673
UCEC
ICGC
PPTPAAT
DEG_SCF_FBW7_1
0.0833
Showing 1 to 19 of 19 entries
Previous
1
Next
Drug responses associated with TNRC6B mutations
Show
10
25
50
100
entries
Search:
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
Showing 0 to 0 of 0 entries
Previous
Next
All proteins holding degron of PPTPAAT
Show
10
25
50
100
entries
Search:
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UPQ9
Trinucleotide repeat-containing gene 6B protein
DEG_SCF_FBW7_1
1732:1738
PPTPAAT
FBXW7
0.9657
More...
Showing 1 to 1 of 1 entries
Previous
1
Next