DegronMD

Uniprot ID: Q9UPQ9

Source protein: Trinucleotide repeat-containing gene 6B protein

Source gene: TNRC6B

Class: DEG_SCF_FBW7_1

Location: 1732:1738

E3 ligase: FBXW7

DEGRON score: 0.9657

ASA_SCORE: 89.7286

COIL: 0.963

CONS_SCORE: 0.3738

DSS_SCORE: 0.6068

HELIX: 0.022

FCONS_SCORE: 0.9151

RIG_SCORE: 0.6358

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1727V	TCGA-60-2698	LUSC	TCGA	PPTPAAT	DEG_SCF_FBW7_1	0.1944
p.L1727V	DO26469	LUSC	ICGC	PPTPAAT	DEG_SCF_FBW7_1	0.1944
p.A1743V	TCGA-AJ-A23O	UCEC	TCGA	PPTPAAT	DEG_SCF_FBW7_1	0.1944
p.V1723A	TCGA-AP-A051	UCEC	TCGA	PPTPAAT	DEG_SCF_FBW7_1	0.0833
p.V1723A	DO42673	UCEC	ICGC	PPTPAAT	DEG_SCF_FBW7_1	0.0833
p.A1741V	TCGA-BR-4361	STAD	TCGA	PPTPAAT	DEG_SCF_FBW7_1	0.25
p.A1741V	DO38887	STAD	ICGC	PPTPAAT	DEG_SCF_FBW7_1	0.25
p.R1725G	TCGA-DA-A1I1	SKCM	TCGA	PPTPAAT	DEG_SCF_FBW7_1	0.1389
p.R1725G	DO37966	SKCM	ICGC	PPTPAAT	DEG_SCF_FBW7_1	0.1389
p.P1735H	TCGA-EB-A24D	SKCM	TCGA	PPTPAAT	DEG_SCF_FBW7_1	0.7694
p.Q1729H	TCGA-EO-A3B0	UCEC	TCGA	PPTPAAT	DEG_SCF_FBW7_1	0.25
p.P1739L	TCGA-FS-A1ZK	SKCM	TCGA	PPTPAAT	DEG_SCF_FBW7_1	0.3056
p.P1739L	DO37474	SKCM	ICGC	PPTPAAT	DEG_SCF_FBW7_1	0.3056
p.S1740G	TCGA-XP-A8T6	ESCA	TCGA	PPTPAAT	DEG_SCF_FBW7_1	0.2778
p.R1725L	DO228818	MALY	ICGC	PPTPAAT	DEG_SCF_FBW7_1	0.1389
p.R1725H	SIDM00216	Colorectal Carcinoma	GDSC	PPTPAAT	DEG_SCF_FBW7_1	0.1389
p.R1725H	SNU-175	large_intestine	COSMIC	PPTPAAT	DEG_SCF_FBW7_1	0.1389
p.A1737V	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPAAT	DEG_SCF_FBW7_1	0.5825
p.A1737V	VAL	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPAAT	DEG_SCF_FBW7_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SCF_FBW7_1	1732:1738	PPTPAAT	FBXW7	0.9657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons