DegronMD

Uniprot ID: Q9UPQ9

Source protein: Trinucleotide repeat-containing gene 6B protein

Source gene: TNRC6B

Class: DEG_SCF_FBW7_2

Location: 864:870

E3 ligase: FBXW7

DEGRON score: 0.9664

ASA_SCORE: 100

COIL: 0.916

CONS_SCORE: 0.3083

DSS_SCORE: 0.8096

HELIX: 0.0731

FCONS_SCORE: 0.6804

RIG_SCORE: 0.5359

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A865V	TCGA-A5-A0G2	UCEC	TCGA	PATPKDE	DEG_SCF_FBW7_2	0.5825
p.A865V	DO41235	UCEC	ICGC	PATPKDE	DEG_SCF_FBW7_2	0.5825
p.G861W	TCGA-D3-A2JL	SKCM	TCGA	PATPKDE	DEG_SCF_FBW7_2	0.25
p.G861W	TCGA-ER-A19F	SKCM	TCGA	PATPKDE	DEG_SCF_FBW7_2	0.25
p.G861W	TCGA-FE-A237	THCA	TCGA	PATPKDE	DEG_SCF_FBW7_2	0.25
p.G861W	DO37679	SKCM	ICGC	PATPKDE	DEG_SCF_FBW7_2	0.25
p.G861W	DO47278	SKCM	ICGC	PATPKDE	DEG_SCF_FBW7_2	0.25
p.G861W	DO40363	THCA	ICGC	PATPKDE	DEG_SCF_FBW7_2	0.25
p.G857V	DO229027	LICA	ICGC	PATPKDE	DEG_SCF_FBW7_2	0.1389
p.P862L	DO222402	MELA	ICGC	PATPKDE	DEG_SCF_FBW7_2	0.2778
p.E870D	SIDM00845	Burkitt's Lymphoma	GDSC	PATPKDE	DEG_SCF_FBW7_2	0.6758
p.E870D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PATPKDE	DEG_SCF_FBW7_2	0.6758
p.E870A	SIDM01140	Ovarian Carcinoma	GDSC	PATPKDE	DEG_SCF_FBW7_2	0.7701
p.P862S	ACH-000928	Endometrial/Uterine Cancer	CCLE	PATPKDE	DEG_SCF_FBW7_2	0.2778
p.T859A	ACH-001529	Endometrial/Uterine Cancer	CCLE	PATPKDE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SCF_FBW7_2	864:870	PATPKDE	FBXW7	0.9664	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons