DegronMD

Uniprot ID: Q70EK8

Source protein: Inactive ubiquitin carboxyl-terminal hydrolase 53

Source gene: USP53

Class: DEG_APCC_KENBOX_2

Location: 629:633

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9916

ASA_SCORE: 98.28

COIL: 0.869

CONS_SCORE: 0.4842

DSS_SCORE: 0.643

HELIX: 0.1136

FCONS_SCORE: 1.1029

RIG_SCORE: 0.6474

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M639I	TCGA-C5-A1M7	CESC	TCGA	PKENP	DEG_APCC_KENBOX_2	0.1667
p.M639I	DO48981	CESC	ICGC	PKENP	DEG_APCC_KENBOX_2	0.1667
p.M639I	DO229038	LICA	ICGC	PKENP	DEG_APCC_KENBOX_2	0.1667
p.P633S	DO229459	SKCA	ICGC	PKENP	DEG_APCC_KENBOX_2	0.5641
p.Q635K	DO229234	THCA	ICGC	PKENP	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60423	Phospholipid-transporting ATPase IK	DEG_APCC_KENBOX_2	527:531	PKENP	APC,CDC20,FZR1	0.8774	More...
P20908	Collagen alpha-1	DEG_APCC_KENBOX_2	1696:1700	PKENP	APC,CDC20,FZR1	0.9351	More...
P78524	DENN domain-containing protein 2B	DEG_APCC_KENBOX_2	496:500	PKENP	APC,CDC20,FZR1	0.9888	More...
Q8TAT2	Fibroblast growth factor-binding protein 3	DEG_APCC_KENBOX_2	195:199	PKENP	APC,CDC20,FZR1	0.9762	More...
Q70EK8	Inactive ubiquitin carboxyl-terminal hydrolase 53	DEG_APCC_KENBOX_2	629:633	PKENP	APC,CDC20,FZR1	0.9916	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons