DegronMD - O60423(ATP8B3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A538T	TCGA-CV-6953	HNSC	TCGA	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.1389
p.A538T	DO14278	HNSC	ICGC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.1389
p.E529K	TCGA-D3-A8GI	SKCM	TCGA	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation altering degron motif	0.7022
p.E529K	DO50284	SKCM	ICGC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation altering degron motif	0.7022
p.E529D	TCGA-E6-A1M0	UCEC	TCGA	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation altering degron motif	0.6758
p.E529D	DO43682	UCEC	ICGC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation altering degron motif	0.6758
p.P20H	TCGA-HE-7130	KIRP	TCGA	PAQTPRST	DEG_SCF_FBW7_1	5:12	Mutation rewiring degron network	0.1111
p.P20H	DO20776	KIRP	ICGC	PAQTPRST	DEG_SCF_FBW7_1	5:12	Mutation rewiring degron network	0.1111
p.Y532C	TCGA-HU-A4GN	STAD	TCGA	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.3056
p.Y532C	DO47833	STAD	ICGC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.3056
p.E522A	TCGA-WE-A8K5	SKCM	TCGA	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.1944
p.E522A	DO51282	SKCM	ICGC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.1944
p.K520N	DO222892	BTCA	ICGC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.1389
p.K520N	DO41193	UCEC	ICGC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.1389
p.K520Q	DO8898	COAD	ICGC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.1389
p.S11N	DO8447	COAD	ICGC	PAQTPRST	DEG_SCF_FBW7_1	5:12	Mutation altering degron motif	0.5958
p.P518T	DO222798	COCA	ICGC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.0833
p.T8N	DO229032	LICA	ICGC	PAQTPRST	DEG_SCF_FBW7_1	5:12	Mutation altering degron motif	0.8166
p.F523V	DO52692	MALY	ICGC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.2222
p.G519E	DO220891	MELA	ICGC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.1111
p.Y532D	SIDM00773	Non-Cancerous	GDSC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.3056
p.Y532D	SIDM00967	Ovarian Carcinoma	GDSC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.3056
p.S521T	SIDM01205	Acute Myeloid Leukemia	GDSC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.1667
p.S521T	SIDM01195	Acute Myeloid Leukemia	GDSC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.1667
p.S521T	ACH-000406	Leukemia	CCLE	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.1667
p.S521T	ACH-002314	Leukemia	CCLE	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.1667
p.S521T	TUR	haematopoietic and lymphoid tissue	COSMIC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.1667
p.F537L	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.1667
p.F537L	ACH-000937	Leukemia	CCLE	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.1667
p.F537L	PF-382	haematopoietic and lymphoid tissue	COSMIC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.1667
p.W518G	HT	haematopoietic and lymphoid tissue	COSMIC	PKENP	DEG_APCC_KENBOX_2	527:531	Mutation rewiring degron network	0.0833

Kaplan plot for ATP8B3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATP8B3

UniProt ID: O60423

Entrez ID: 148229

Protein name: Phospholipid-transporting ATPase IK (EC 7.6.2.1) (ATPase class I type 8B member 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATP8B3 in