DegronMD

Uniprot ID: O60423

Source protein: Phospholipid-transporting ATPase IK

Source gene: ATP8B3

Class: DEG_APCC_KENBOX_2

Location: 527:531

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8774

ASA_SCORE: 77.66

COIL: 0.8056

CONS_SCORE: 0.2988

DSS_SCORE: 0.3915

HELIX: 0.1268

FCONS_SCORE: 0.8654

RIG_SCORE: 0.7789

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A538T	TCGA-CV-6953	HNSC	TCGA	PKENP	DEG_APCC_KENBOX_2	0.1389
p.A538T	DO14278	HNSC	ICGC	PKENP	DEG_APCC_KENBOX_2	0.1389
p.E529K	TCGA-D3-A8GI	SKCM	TCGA	PKENP	DEG_APCC_KENBOX_2	0.7022
p.E529K	DO50284	SKCM	ICGC	PKENP	DEG_APCC_KENBOX_2	0.7022
p.E529D	TCGA-E6-A1M0	UCEC	TCGA	PKENP	DEG_APCC_KENBOX_2	0.6758
p.E529D	DO43682	UCEC	ICGC	PKENP	DEG_APCC_KENBOX_2	0.6758
p.Y532C	TCGA-HU-A4GN	STAD	TCGA	PKENP	DEG_APCC_KENBOX_2	0.3056
p.Y532C	DO47833	STAD	ICGC	PKENP	DEG_APCC_KENBOX_2	0.3056
p.E522A	TCGA-WE-A8K5	SKCM	TCGA	PKENP	DEG_APCC_KENBOX_2	0.1944
p.E522A	DO51282	SKCM	ICGC	PKENP	DEG_APCC_KENBOX_2	0.1944
p.K520N	DO222892	BTCA	ICGC	PKENP	DEG_APCC_KENBOX_2	0.1389
p.K520N	DO41193	UCEC	ICGC	PKENP	DEG_APCC_KENBOX_2	0.1389
p.K520Q	DO8898	COAD	ICGC	PKENP	DEG_APCC_KENBOX_2	0.1389
p.P518T	DO222798	COCA	ICGC	PKENP	DEG_APCC_KENBOX_2	0.0833
p.F523V	DO52692	MALY	ICGC	PKENP	DEG_APCC_KENBOX_2	0.2222
p.G519E	DO220891	MELA	ICGC	PKENP	DEG_APCC_KENBOX_2	0.1111
p.Y532D	SIDM00773	Non-Cancerous	GDSC	PKENP	DEG_APCC_KENBOX_2	0.3056
p.Y532D	SIDM00967	Ovarian Carcinoma	GDSC	PKENP	DEG_APCC_KENBOX_2	0.3056
p.S521T	SIDM01205	Acute Myeloid Leukemia	GDSC	PKENP	DEG_APCC_KENBOX_2	0.1667
p.S521T	SIDM01195	Acute Myeloid Leukemia	GDSC	PKENP	DEG_APCC_KENBOX_2	0.1667
p.S521T	ACH-000406	Leukemia	CCLE	PKENP	DEG_APCC_KENBOX_2	0.1667
p.S521T	ACH-002314	Leukemia	CCLE	PKENP	DEG_APCC_KENBOX_2	0.1667
p.S521T	TUR	haematopoietic_and_lymphoid_tissue	COSMIC	PKENP	DEG_APCC_KENBOX_2	0.1667
p.F537L	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PKENP	DEG_APCC_KENBOX_2	0.1667
p.F537L	ACH-000937	Leukemia	CCLE	PKENP	DEG_APCC_KENBOX_2	0.1667
p.F537L	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PKENP	DEG_APCC_KENBOX_2	0.1667
p.W518G	HT	haematopoietic_and_lymphoid_tissue	COSMIC	PKENP	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60423	Phospholipid-transporting ATPase IK	DEG_APCC_KENBOX_2	527:531	PKENP	APC,CDC20,FZR1	0.8774	More...
P20908	Collagen alpha-1	DEG_APCC_KENBOX_2	1696:1700	PKENP	APC,CDC20,FZR1	0.9351	More...
P78524	DENN domain-containing protein 2B	DEG_APCC_KENBOX_2	496:500	PKENP	APC,CDC20,FZR1	0.9888	More...
Q8TAT2	Fibroblast growth factor-binding protein 3	DEG_APCC_KENBOX_2	195:199	PKENP	APC,CDC20,FZR1	0.9762	More...
Q70EK8	Inactive ubiquitin carboxyl-terminal hydrolase 53	DEG_APCC_KENBOX_2	629:633	PKENP	APC,CDC20,FZR1	0.9916	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKENP

Degron related mutations and impact score

Drug responses associated with ATP8B3 mutations

All proteins holding degron of PKENP