DegronMD

Uniprot ID: P78524

Source protein: DENN domain-containing protein 2B

Source gene: DENND2B

Class: DEG_APCC_KENBOX_2

Location: 496:500

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9888

ASA_SCORE: 82.16

COIL: 0.8482

CONS_SCORE: 0.4202

DSS_SCORE: 0.532

HELIX: 0.104

FCONS_SCORE: 1.0123

RIG_SCORE: 0.6948

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y488C	SIDM00561	Other Blood Cancers	GDSC	PKENP	DEG_APCC_KENBOX_2	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60423	Phospholipid-transporting ATPase IK	DEG_APCC_KENBOX_2	527:531	PKENP	APC,CDC20,FZR1	0.8774	More...
P20908	Collagen alpha-1	DEG_APCC_KENBOX_2	1696:1700	PKENP	APC,CDC20,FZR1	0.9351	More...
P78524	DENN domain-containing protein 2B	DEG_APCC_KENBOX_2	496:500	PKENP	APC,CDC20,FZR1	0.9888	More...
Q8TAT2	Fibroblast growth factor-binding protein 3	DEG_APCC_KENBOX_2	195:199	PKENP	APC,CDC20,FZR1	0.9762	More...
Q70EK8	Inactive ubiquitin carboxyl-terminal hydrolase 53	DEG_APCC_KENBOX_2	629:633	PKENP	APC,CDC20,FZR1	0.9916	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons