FGFBP3
UniProt ID: Q8TAT2
Entrez ID: 143282
Protein name: Fibroblast growth factor-binding protein 3 (FGF-BP3) (FGF-binding protein 3) (FGFBP-3)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability. {ECO:00...
FUNCTION: Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability. {ECO:0000269|PubMed:18669637}.
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GO - Biological processes (BP):
cell-cell signaling [GO:0007267]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of vascular permeability [GO:0043117]...
cell-cell signaling [GO:0007267]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of vascular permeability [GO:0043117]
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GO - Molecular function (MF):
fibroblast growth factor binding [GO:0017134]; growth factor binding [GO:0019838]; heparin binding [GO:0008201]...
fibroblast growth factor binding [GO:0017134]; growth factor binding [GO:0019838]; heparin binding [GO:0008201]
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GO - Cellular component (CC):
collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]...
collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]
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FGFBP3
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*NOTE: the Kaplan plots were collected from OncoLnc