DENND2B
UniProt ID: P78524
Entrez ID: 6764
Protein name: DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|Pu...
FUNCTION: [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}.
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GO - Biological processes (BP):
positive regulation of ERK1 and ERK2 cascade [GO:0070374]...
positive regulation of ERK1 and ERK2 cascade [GO:0070374]
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GO - Molecular function (MF):
guanyl-nucleotide exchange factor activity [GO:0005085]...
guanyl-nucleotide exchange factor activity [GO:0005085]
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GO - Cellular component (CC):
cell cortex [GO:0005938]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]...
cell cortex [GO:0005938]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]
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DENND2B
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Kaplan plot for DENND2B in
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*NOTE: the Kaplan plots were collected from OncoLnc