DegronMD

Uniprot ID: O60423

Source protein: Phospholipid-transporting ATPase IK

Source gene: ATP8B3

Class: DEG_SCF_FBW7_1

Location: 5:12

E3 ligase: FBXW7

DEGRON score: 0.5827

ASA_SCORE: 91.05

COIL: 0.8988

CONS_SCORE: 0.1323

DSS_SCORE: 0.9535

HELIX: 0.0625

FCONS_SCORE: 1

RIG_SCORE: 0.5719

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P20H	TCGA-HE-7130	KIRP	TCGA	PAQTPRST	DEG_SCF_FBW7_1	0.1111
p.P20H	DO20776	KIRP	ICGC	PAQTPRST	DEG_SCF_FBW7_1	0.1111
p.S11N	DO8447	COAD	ICGC	PAQTPRST	DEG_SCF_FBW7_1	0.5958
p.T8N	DO229032	LICA	ICGC	PAQTPRST	DEG_SCF_FBW7_1	0.8166

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60423	Phospholipid-transporting ATPase IK	DEG_SCF_FBW7_1	5:12	PAQTPRST	FBXW7	0.5827	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons