DegronMD

Uniprot ID: P20908

Source protein: Collagen alpha-1

Source gene: COL5A1

Class: DEG_SCF_SKP2-CKS1_1

Location: 287:294

E3 ligase: SKP2,CSK1

DEGRON score: 0.8431

ASA_SCORE: 83.0625

COIL: 0.921

CONS_SCORE: 0.2106

DSS_SCORE: 0.6988

HELIX: 0.0226

FCONS_SCORE: 0.9685

RIG_SCORE: 0.6227

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E284K	TCGA-2W-A8YY	CESC	TCGA	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.25
p.E284K	TCGA-AP-A056	UCEC	TCGA	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.25
p.E284K	TCGA-B5-A3FA	UCEC	TCGA	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.25
p.E284K	DO223732	CESC	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.25
p.E284K	DO234418	ESAD	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.25
p.E284K	DO52402	UCEC	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.25
p.E284K	DO43971	UCEC	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.25
p.E284K	SIDM01449	Pancreatic Carcinoma	GDSC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.25
p.D282Y	TCGA-AZ-4315	COAD	TCGA	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.1944
p.D282Y	DO8842	COAD	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P278T	TCGA-BS-A0UJ	UCEC	TCGA	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.0833
p.P278T	DO42745	UCEC	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.0833
p.V297M	TCGA-CM-6163	COAD	TCGA	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.25
p.V297M	DO9194	COAD	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.25
p.G287R	TCGA-IH-A3EA	SKCM	TCGA	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.6457
p.G287R	DO37667	SKCM	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.6457
p.G287E	TCGA-W3-AA1V	SKCM	TCGA	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.6087
p.G287E	DO51276	SKCM	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.6087
p.P292T	DO233697	GACA	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.7031
p.P292H	DO45153	LIRI	ICGC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.7694
p.E289K	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.7022
p.E289K	ACH-000647	Esophageal Cancer	CCLE	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.7022
p.E289K	TE-1	oesophagus	COSMIC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.7022
p.A300S	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.1667
p.A300S	ACH-000488	Esophageal Cancer	CCLE	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.1667
p.A300S	TE-11	oesophagus	COSMIC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.1667
p.E281K	SIDM01088	Endometrial Carcinoma	GDSC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.1667
p.E281K	ACH-000965	Endometrial/Uterine Cancer	CCLE	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.1667
p.E281K	RL95-2	endometrium	COSMIC	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.1667
p.A300T	ACH-001664	Gastric Cancer	CCLE	GKEPTPSK	DEG_SCF_SKP2-CKS1_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GKEPTPSK

Degron related mutations and impact score

Drug responses associated with COL5A1 mutations

All proteins holding degron of GKEPTPSK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20908	Collagen alpha-1	DEG_SCF_SKP2-CKS1_1	287:294	GKEPTPSK	SKP2,CSK1	0.8431	More...