DegronMD

Uniprot ID: Q9NR99

Source protein: Matrix-remodeling-associated protein 5

Source gene: MXRA5

Class: DEG_SPOP_SBC_1

Location: 1396:1400

E3 ligase: SPOP

DEGRON score: 0.9951

ASA_SCORE: 74.52

COIL: 0.6972

CONS_SCORE: 0.2996

DSS_SCORE: 0.6551

HELIX: 0.0212

FCONS_SCORE: 0.9513

RIG_SCORE: 0.7111

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1390S	TCGA-EE-A3AC	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	0.1667
p.R1390S	DO37631	SKCM	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1667
p.G1389R	TCGA-FD-A3SO	BLCA	TCGA	PVTTS	DEG_SPOP_SBC_1	0.1389
p.G1389R	DO569	BLCA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1389
p.E1402K	TCGA-FS-A1ZK	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	0.2778
p.E1402K	DO37474	SKCM	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2778
p.E1402K	SIDM00449	B-Lymphoblastic Leukemia	GDSC	PVTTS	DEG_SPOP_SBC_1	0.2778
p.E1402K	ACH-000922	Leukemia	CCLE	PVTTS	DEG_SPOP_SBC_1	0.2778
p.E1402K	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.2778
p.G1401V	TCGA-L9-A8F4	LUAD	TCGA	PVTTS	DEG_SPOP_SBC_1	0.3056
p.G1401V	DO49876	LUAD	ICGC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.A1386T	TCGA-QF-A5YS	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.0556
p.A1386T	DO52426	UCEC	ICGC	PVTTS	DEG_SPOP_SBC_1	0.0556
p.G1394D	DO229010	COCA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2778
p.G1394D	DO229013	COCA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2778
p.G1394D	DO229016	COCA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2778
p.G1394D	DO229003	COCA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2778
p.G1394D	DO229005	COCA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2778
p.G1394D	DO229489	LAML	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2778
p.G1394D	DO230550	LUSC	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2778
p.P1407S	DO233865	GACA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1389
p.E1402G	DO222396	MELA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2778
p.G1401E	SIDM00527	Colorectal Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.G1401E	ACH-000935	Colon/Colorectal Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	0.3056
p.G1401E	MDST8	large_intestine	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.G1401R	SIDM00527	Colorectal Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.3056
p.G1401R	ACH-000935	Colon/Colorectal Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	0.3056
p.G1401R	MDST8	large_intestine	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95405	Zinc finger FYVE domain-containing protein 9	DEG_SPOP_SBC_1	866:870	PVTTS	SPOP	0.9916	More...
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	453:457	PVTTS	SPOP	0.8941	More...
P42858	Huntingtin	DEG_SPOP_SBC_1	1218:1222	PVTTS	SPOP	0.9924	More...
Q01167	Forkhead box protein K2	DEG_SPOP_SBC_1	457:461	PVTTS	SPOP	0.9295	More...
Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A	DEG_SPOP_SBC_1	396:400	PVTTS	SPOP	0.9907	More...
Q15751	Probable E3 ubiquitin-protein ligase HERC1	DEG_SPOP_SBC_1	2633:2637	PVTTS	SPOP	0.9265	More...
Q2TAL8	Transcriptional regulator QRICH1	DEG_SPOP_SBC_1	79:83	PVTTS	SPOP	0.9415	More...
Q5T5P2	Sickle tail protein homolog	DEG_SPOP_SBC_1	1114:1118	PVTTS	SPOP	0.9913	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	541:545	PVTTS	SPOP	0.876	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	954:958	PVTTS	SPOP	0.9503	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1131:1135	PVTTS	SPOP	0.8176	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1367:1371	PVTTS	SPOP	0.5669	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1720:1724	PVTTS	SPOP	0.7511	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2250:2254	PVTTS	SPOP	0.7066	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2722:2726	PVTTS	SPOP	0.9789	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2781:2785	PVTTS	SPOP	0.7773	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2840:2844	PVTTS	SPOP	0.6573	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3135:3139	PVTTS	SPOP	0.7818	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3194:3198	PVTTS	SPOP	0.8497	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3370:3374	PVTTS	SPOP	0.9693	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3724:3728	PVTTS	SPOP	0.7788	More...
Q7Z7B0	Filamin-A-interacting protein 1	DEG_SPOP_SBC_1	1133:1137	PVTTS	SPOP	0.9971	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8904:8908	PVTTS	SPOP	0.8117	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10028:10032	PVTTS	SPOP	0.5276	More...
Q96JN0	Ligand-dependent corepressor	DEG_SPOP_SBC_1	38:42	PVTTS	SPOP	0.9743	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	346:350	PVTTS	SPOP	0.5472	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	603:607	PVTTS	SPOP	0.9995	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SPOP_SBC_1	1396:1400	PVTTS	SPOP	0.9951	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	278:282	PVTTS	SPOP	0.9519	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1661:1665	PVTTS	SPOP	0.9211	More...
Q6ZTI0	Putative uncharacterized protein FLJ44636	DEG_SPOP_SBC_1	9:13	PVTTS	SPOP	0.9393	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTTS

Degron related mutations and impact score

Drug responses associated with MXRA5 mutations

All proteins holding degron of PVTTS