DegronMD - O95405(ZFYVE9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G336C	TCGA-28-2513	GBM	TCGA	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.6489
p.G336C	DO12766	GBM	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.6489
p.G336C	DO229037	LICA	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.6489
p.L340F	TCGA-55-1592	LUAD	TCGA	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.6981
p.L340F	DO23556	LUAD	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.6981
p.R351K	TCGA-78-8640	LUAD	TCGA	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.0556
p.R351K	DO45340	LUAD	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.0556
p.L872Q	TCGA-85-7710	LUSC	TCGA	PVTTS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.2778
p.L872Q	DO26826	LUSC	ICGC	PVTTS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.2778
p.S870N	TCGA-AP-A1DK	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	866:870	Mutation altering degron motif	0.7069
p.S870N	DO42033	UCEC	ICGC	PVTTS	DEG_SPOP_SBC_1	866:870	Mutation altering degron motif	0.7069
p.R334Q	TCGA-AX-A1C5	UCEC	TCGA	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.7329
p.R334Q	DO41422	UCEC	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.7329
p.L341F	TCGA-FD-A6TI	BLCA	TCGA	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.587
p.L341F	DO49764	BLCA	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.587
p.E331D	TCGA-FI-A2D5	UCEC	TCGA	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.2778
p.E331D	DO41331	UCEC	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.2778
p.A324T	DO230309	COCA	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.0833
p.A324T	SIDM00333	Endometrial Carcinoma	GDSC	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.0833
p.A324T	ACH-000988	Endometrial/Uterine Cancer	CCLE	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.0833
p.A324T	MFE-319	endometrium	COSMIC	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.0833
p.P338H	DO230335	COCA	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.6583
p.G350E	DO233286	GACA	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.0833
p.V859A	DO231959	LICA	ICGC	PVTTS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.1389
p.A324E	DO50791	LIRI	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.0833
p.T876M	DO228855	MALY	ICGC	PVTTS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.1667
p.T856N	DO229248	THCA	ICGC	PVTTS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.0556
p.A858T	SIDM02015	Colorectal Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.1111
p.T876K	SIDM01063	Acute Myeloid Leukemia	GDSC	PVTTS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.1667
p.T876K	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	PVTTS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.1667
p.P873S	SIDM01622	Breast Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.25
p.P873S	ACH-000721	Breast Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.25
p.A874E	ACH-001518	Endometrial/Uterine Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.2222
p.D879A	Farage	haematopoietic and lymphoid tissue	COSMIC	PVTTS	DEG_SPOP_SBC_1	866:870	Mutation rewiring degron network	0.0833

Kaplan plot for ZFYVE9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFYVE9

UniProt ID: O95405

Entrez ID: 9372

Protein name: Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZFYVE9 in