DegronMD

Uniprot ID: O95405

Source protein: Zinc finger FYVE domain-containing protein 9

Source gene: ZFYVE9

Class: DEG_APCC_DBOX_1

Location: 333:341

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.987

ASA_SCORE: 77.1778

COIL: 0.7269

CONS_SCORE: 0.3668

DSS_SCORE: 0.6144

HELIX: 0.2323

FCONS_SCORE: 1.022

RIG_SCORE: 0.7183

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R334Q	TCGA-AX-A1C5	UCEC	TCGA	LRSGLPLLL	DEG_APCC_DBOX_1	0.7329
p.R334Q	DO41422	UCEC	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	0.7329
p.L340F	TCGA-55-1592	LUAD	TCGA	LRSGLPLLL	DEG_APCC_DBOX_1	0.6981
p.L340F	DO23556	LUAD	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	0.6981
p.P338H	DO230335	COCA	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	0.6583
p.G336C	TCGA-28-2513	GBM	TCGA	LRSGLPLLL	DEG_APCC_DBOX_1	0.6489
p.G336C	DO12766	GBM	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	0.6489
p.G336C	DO229037	LICA	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	0.6489
p.L341F	TCGA-FD-A6TI	BLCA	TCGA	LRSGLPLLL	DEG_APCC_DBOX_1	0.587
p.L341F	DO49764	BLCA	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	0.587
p.E331D	TCGA-FI-A2D5	UCEC	TCGA	LRSGLPLLL	DEG_APCC_DBOX_1	0.2778
p.E331D	DO41331	UCEC	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	0.2778
p.A324T	DO230309	COCA	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	0.0833
p.A324T	SIDM00333	Endometrial Carcinoma	GDSC	LRSGLPLLL	DEG_APCC_DBOX_1	0.0833
p.A324T	ACH-000988	Endometrial/Uterine Cancer	CCLE	LRSGLPLLL	DEG_APCC_DBOX_1	0.0833
p.A324T	MFE-319	endometrium	COSMIC	LRSGLPLLL	DEG_APCC_DBOX_1	0.0833
p.G350E	DO233286	GACA	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	0.0833
p.A324E	DO50791	LIRI	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	0.0833
p.R351K	TCGA-78-8640	LUAD	TCGA	LRSGLPLLL	DEG_APCC_DBOX_1	0.0556
p.R351K	DO45340	LUAD	ICGC	LRSGLPLLL	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95405	Zinc finger FYVE domain-containing protein 9	DEG_APCC_DBOX_1	333:341	LRSGLPLLL	APC,CDC20,FZR1	0.987	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons