DegronMD

Uniprot ID: O95405

Source protein: Zinc finger FYVE domain-containing protein 9

Source gene: ZFYVE9

Class: DEG_SPOP_SBC_1

Location: 866:870

E3 ligase: SPOP

DEGRON score: 0.9916

ASA_SCORE: 85.36

COIL: 0.9538

CONS_SCORE: 0.4089

DSS_SCORE: 0.4758

HELIX: 0.0136

FCONS_SCORE: 1.0933

RIG_SCORE: 0.7325

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S870N	TCGA-AP-A1DK	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.7069
p.S870N	DO42033	UCEC	ICGC	PVTTS	DEG_SPOP_SBC_1	0.7069
p.L872Q	TCGA-85-7710	LUSC	TCGA	PVTTS	DEG_SPOP_SBC_1	0.2778
p.L872Q	DO26826	LUSC	ICGC	PVTTS	DEG_SPOP_SBC_1	0.2778
p.P873S	SIDM01622	Breast Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.25
p.P873S	ACH-000721	Breast Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	0.25
p.A874E	ACH-001518	Endometrial/Uterine Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	0.2222
p.T876M	DO228855	MALY	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1667
p.T876K	SIDM01063	Acute Myeloid Leukemia	GDSC	PVTTS	DEG_SPOP_SBC_1	0.1667
p.T876K	HD-MY-Z	haematopoietic_and_lymphoid_tissue	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.1667
p.V859A	DO231959	LICA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.1389
p.A858T	SIDM02015	Colorectal Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	0.1111
p.D879A	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PVTTS	DEG_SPOP_SBC_1	0.0833
p.T856N	DO229248	THCA	ICGC	PVTTS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 14 of 14 entries

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Drug responses associated with ZFYVE9 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PVTTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	453:457	PVTTS	SPOP	0.8941	More...
Q7Z7B0	Filamin-A-interacting protein 1	DEG_SPOP_SBC_1	1133:1137	PVTTS	SPOP	0.9971	More...
Q01167	Forkhead box protein K2	DEG_SPOP_SBC_1	457:461	PVTTS	SPOP	0.9295	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	278:282	PVTTS	SPOP	0.9519	More...
P42858	Huntingtin	DEG_SPOP_SBC_1	1218:1222	PVTTS	SPOP	0.9924	More...
Q96JN0	Ligand-dependent corepressor	DEG_SPOP_SBC_1	38:42	PVTTS	SPOP	0.9743	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SPOP_SBC_1	1396:1400	PVTTS	SPOP	0.9951	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8904:8908	PVTTS	SPOP	0.8117	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10028:10032	PVTTS	SPOP	0.5276	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	541:545	PVTTS	SPOP	0.876	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	954:958	PVTTS	SPOP	0.9503	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1131:1135	PVTTS	SPOP	0.8176	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1367:1371	PVTTS	SPOP	0.5669	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1720:1724	PVTTS	SPOP	0.7511	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2250:2254	PVTTS	SPOP	0.7066	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2722:2726	PVTTS	SPOP	0.9789	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2781:2785	PVTTS	SPOP	0.7773	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2840:2844	PVTTS	SPOP	0.6573	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3135:3139	PVTTS	SPOP	0.7818	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3194:3198	PVTTS	SPOP	0.8497	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3370:3374	PVTTS	SPOP	0.9693	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3724:3728	PVTTS	SPOP	0.7788	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	346:350	PVTTS	SPOP	0.5472	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1661:1665	PVTTS	SPOP	0.9211	More...
Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A	DEG_SPOP_SBC_1	396:400	PVTTS	SPOP	0.9907	More...

Showing 1 to 25 of 31 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTTS

Degron related mutations and impact score

Drug responses associated with ZFYVE9 mutations

All proteins holding degron of PVTTS