DegronMD

Uniprot ID: Q9NR99

Source protein: Matrix-remodeling-associated protein 5

Source gene: MXRA5

Class: DEG_COP1_1

Location: 1193:1204

E3 ligase: COP1

DEGRON score: 0.9477

ASA_SCORE: 77.7417

COIL: 0.7297

CONS_SCORE: 0.2798

DSS_SCORE: 0.4837

HELIX: 0.0507

FCONS_SCORE: 0.9667

RIG_SCORE: 0.7291

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1191N	TCGA-19-5956	GBM	TCGA	SSQVESSLVPTA	DEG_COP1_1	0.2778
p.K1191N	DO13863	GBM	ICGC	SSQVESSLVPTA	DEG_COP1_1	0.2778
p.Q1195K	TCGA-49-4488	LUAD	TCGA	SSQVESSLVPTA	DEG_COP1_1	0.5833
p.Q1195K	DO24750	LUAD	ICGC	SSQVESSLVPTA	DEG_COP1_1	0.5833
p.D1207N	TCGA-AC-A23H	BRCA	TCGA	SSQVESSLVPTA	DEG_COP1_1	0.25
p.D1207N	DO2401	BRCA	ICGC	SSQVESSLVPTA	DEG_COP1_1	0.25
p.S1199Y	TCGA-AX-A0J0	UCEC	TCGA	SSQVESSLVPTA	DEG_COP1_1	0.6009
p.S1199Y	DO41133	UCEC	ICGC	SSQVESSLVPTA	DEG_COP1_1	0.6009
p.W1205L	TCGA-D3-A1QA	SKCM	TCGA	SSQVESSLVPTA	DEG_COP1_1	0.3056
p.W1205L	DO47469	SKCM	ICGC	SSQVESSLVPTA	DEG_COP1_1	0.3056
p.S1199F	TCGA-EB-A5UM	SKCM	TCGA	SSQVESSLVPTA	DEG_COP1_1	0.6871
p.S1199F	DO47282	SKCM	ICGC	SSQVESSLVPTA	DEG_COP1_1	0.6871
p.P1202S	TCGA-EE-A3J5	SKCM	TCGA	SSQVESSLVPTA	DEG_COP1_1	0.6752
p.P1202S	DO47331	SKCM	ICGC	SSQVESSLVPTA	DEG_COP1_1	0.6752
p.P1188H	TCGA-FS-A1ZB	SKCM	TCGA	SSQVESSLVPTA	DEG_COP1_1	0.1944
p.P1188H	DO37886	SKCM	ICGC	SSQVESSLVPTA	DEG_COP1_1	0.1944
p.S1193P	TCGA-J2-A4AD	LUAD	TCGA	SSQVESSLVPTA	DEG_COP1_1	0.6752
p.S1193P	DO23915	LUAD	ICGC	SSQVESSLVPTA	DEG_COP1_1	0.6752
p.S1193L	TCGA-W3-AA1V	SKCM	TCGA	SSQVESSLVPTA	DEG_COP1_1	0.7667
p.S1193L	DO51276	SKCM	ICGC	SSQVESSLVPTA	DEG_COP1_1	0.7667
p.P1213L	DO222576	COCA	ICGC	SSQVESSLVPTA	DEG_COP1_1	0.0833
p.E1197D	DO50343	ESAD	ICGC	SSQVESSLVPTA	DEG_COP1_1	0.5647
p.D1189N	SIDM00704	Small Cell Lung Carcinoma	GDSC	SSQVESSLVPTA	DEG_COP1_1	0.2222
p.D1189N	ACH-000639	Lung Cancer	CCLE	SSQVESSLVPTA	DEG_COP1_1	0.2222
p.D1189N	NCI-H211	lung	COSMIC	SSQVESSLVPTA	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR99	Matrix-remodeling-associated protein 5	DEG_COP1_1	1193:1204	SSQVESSLVPTA	COP1	0.9477	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons