DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
KYQIYQD
Uniprot ID:
Q9NR99
Source protein:
Matrix-remodeling-associated protein 5
Source gene:
MXRA5
Class:
LIG_APCC_ABBAyCdc20_2
Location:
2394:2400
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.577
ASA_SCORE:
79.9429
COIL:
0.4961
CONS_SCORE:
0.4368
DSS_SCORE:
0.289
HELIX:
0.0056
FCONS_SCORE:
1.0899
RIG_SCORE:
0.8585
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Y2398S
TCGA-28-1760
GBM
TCGA
KYQIYQD
LIG_APCC_ABBAyCdc20_2
0.712
p.Y2398S
DO13725
GBM
ICGC
KYQIYQD
LIG_APCC_ABBAyCdc20_2
0.712
p.A2408D
TCGA-B5-A3FA
UCEC
TCGA
KYQIYQD
LIG_APCC_ABBAyCdc20_2
0.1111
p.A2408D
DO52402
UCEC
ICGC
KYQIYQD
LIG_APCC_ABBAyCdc20_2
0.1111
p.G2401D
TCGA-BR-6452
STAD
TCGA
KYQIYQD
LIG_APCC_ABBAyCdc20_2
0.3056
p.G2401D
DO38404
STAD
ICGC
KYQIYQD
LIG_APCC_ABBAyCdc20_2
0.3056
p.A2408S
TCGA-D5-6530
COAD
TCGA
KYQIYQD
LIG_APCC_ABBAyCdc20_2
0.1111
p.A2408S
TCGA-FP-7829
STAD
TCGA
KYQIYQD
LIG_APCC_ABBAyCdc20_2
0.1111
p.A2408S
DO8312
COAD
ICGC
KYQIYQD
LIG_APCC_ABBAyCdc20_2
0.1111
p.A2408S
DO38308
STAD
ICGC
KYQIYQD
LIG_APCC_ABBAyCdc20_2
0.1111
p.Q2406R
TCGA-E9-A249
BRCA
TCGA
KYQIYQD
LIG_APCC_ABBAyCdc20_2
0.1667
p.Q2406R
DO3856
BRCA
ICGC
KYQIYQD
LIG_APCC_ABBAyCdc20_2
0.1667
p.R2410C
TCGA-EO-A3L0
UCEC
TCGA
KYQIYQD
LIG_APCC_ABBAyCdc20_2
0.0556
p.R2410C
DO219775
UCEC
ICGC
KYQIYQD
LIG_APCC_ABBAyCdc20_2
0.0556
p.A2408T
DO228559
LICA
ICGC
KYQIYQD
LIG_APCC_ABBAyCdc20_2
0.1111
p.L2404F
DO48682
LIRI
ICGC
KYQIYQD
LIG_APCC_ABBAyCdc20_2
0.2222
p.Y2398H
ACH-000791
Lung Cancer
CCLE
KYQIYQD
LIG_APCC_ABBAyCdc20_2
0.6118
Drug responses associated with MXRA5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KYQIYQD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NR99
Matrix-remodeling-associated protein 5
LIG_APCC_ABBAyCdc20_2
2394:2400
KYQIYQD
APC,CDC20,FZR1
0.577
More...