DegronMD

Uniprot ID: Q9NR99

Source protein: Matrix-remodeling-associated protein 5

Source gene: MXRA5

Class: DEG_SCF_FBW7_2

Location: 1268:1274

E3 ligase: FBXW7

DEGRON score: 0.6311

ASA_SCORE: 83.4857

COIL: 0.7861

CONS_SCORE: 0.2788

DSS_SCORE: 0.5852

HELIX: 0.0257

FCONS_SCORE: 0.7981

RIG_SCORE: 0.6934

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1280K	TCGA-06-0745	GBM	TCGA	IVTPSSE	DEG_SCF_FBW7_2	0.1667
p.R1280K	DO12034	GBM	ICGC	IVTPSSE	DEG_SCF_FBW7_2	0.1667
p.R1266I	TCGA-06-5416	GBM	TCGA	IVTPSSE	DEG_SCF_FBW7_2	0.2778
p.R1266I	DO10880	GBM	ICGC	IVTPSSE	DEG_SCF_FBW7_2	0.2778
p.S1272N	TCGA-AB-2808	LAML	TCGA	IVTPSSE	DEG_SCF_FBW7_2	0.5958
p.S1272N	DO21487	LAML	ICGC	IVTPSSE	DEG_SCF_FBW7_2	0.5958
p.L1277I	TCGA-AP-A1E0	UCEC	TCGA	IVTPSSE	DEG_SCF_FBW7_2	0.25
p.L1277I	DO43154	UCEC	ICGC	IVTPSSE	DEG_SCF_FBW7_2	0.25
p.S1283Y	TCGA-B5-A1MR	UCEC	TCGA	IVTPSSE	DEG_SCF_FBW7_2	0.0833
p.S1283Y	DO41758	UCEC	ICGC	IVTPSSE	DEG_SCF_FBW7_2	0.0833
p.S1273P	TCGA-CA-6717	COAD	TCGA	IVTPSSE	DEG_SCF_FBW7_2	0.5641
p.S1273P	DO8264	COAD	ICGC	IVTPSSE	DEG_SCF_FBW7_2	0.5641
p.P1261L	TCGA-D3-A51J	SKCM	TCGA	IVTPSSE	DEG_SCF_FBW7_2	0.1389
p.P1261L	DO47359	SKCM	ICGC	IVTPSSE	DEG_SCF_FBW7_2	0.1389
p.P1261S	TCGA-D3-A51J	SKCM	TCGA	IVTPSSE	DEG_SCF_FBW7_2	0.1389
p.P1261S	DO47359	SKCM	ICGC	IVTPSSE	DEG_SCF_FBW7_2	0.1389
p.R1280I	TCGA-EY-A1GI	UCEC	TCGA	IVTPSSE	DEG_SCF_FBW7_2	0.1667
p.R1280I	DO41211	UCEC	ICGC	IVTPSSE	DEG_SCF_FBW7_2	0.1667
p.N1267D	TCGA-G4-6588	COAD	TCGA	IVTPSSE	DEG_SCF_FBW7_2	0.3056
p.N1267D	DO10140	COAD	ICGC	IVTPSSE	DEG_SCF_FBW7_2	0.3056
p.P1259L	TCGA-Z2-A8RT	SKCM	TCGA	IVTPSSE	DEG_SCF_FBW7_2	0.0833
p.P1259L	DO51301	SKCM	ICGC	IVTPSSE	DEG_SCF_FBW7_2	0.0833
p.S1258R	DO229045	LICA	ICGC	IVTPSSE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SCF_FBW7_2	1268:1274	IVTPSSE	FBXW7	0.6311	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons