DegronMD

Uniprot ID: Q15735

Source protein: Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Source gene: INPP5J

Class: DEG_APCC_DBOX_1

Location: 55:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9568

ASA_SCORE: 77.9

COIL: 0.8707

CONS_SCORE: 0.2647

DSS_SCORE: 0.5126

HELIX: 0.0892

FCONS_SCORE: 1.0233

RIG_SCORE: 0.697

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G56W	DO229027	LICA	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.7825
p.V62E	SCC-4	upper_aerodigestive_tract	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.7693
p.G57C	DO45462	LUSC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.76
p.G55V	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.7532
p.R63Q	DO20396	KIRC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.7329
p.R63Q	DO42977	UCEC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.7329
p.S59N	DO41235	UCEC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.7069
p.T58N	TCGA-AJ-A3BH	UCEC	TCGA	PRLALAPVG	DEG_APCC_DBOX_1	0.7055
p.P60S	DO37535	SKCM	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.6752
p.S53L	TCGA-CV-7104	HNSC	TCGA	PRLALAPVG	DEG_APCC_DBOX_1	0.2778
p.S53L	DO14798	HNSC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.2778
p.A53S	DO229015	LICA	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.2778
p.A53S	DO229027	LICA	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.2778
p.R65Q	SIDM00410	Other Blood Cancers	GDSC	PRLALAPVG	DEG_APCC_DBOX_1	0.2778
p.R65Q	YT	haematopoietic_and_lymphoid_tissue	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.2778
p.S65G	OCUM-1	stomach	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.2778
p.T66N	TCGA-A8-A09A	BRCA	TCGA	PRLALAPVG	DEG_APCC_DBOX_1	0.25
p.P52S	SIDM01193	Glioma	GDSC	PRLALAPVG	DEG_APCC_DBOX_1	0.25
p.P52S	SIDM01768	Melanoma	GDSC	PRLALAPVG	DEG_APCC_DBOX_1	0.25
p.P52S	ACH-000040	Brain Cancer	CCLE	PRLALAPVG	DEG_APCC_DBOX_1	0.25
p.P52S	ACH-000899	Skin Cancer	CCLE	PRLALAPVG	DEG_APCC_DBOX_1	0.25
p.P52S	U-118-MG	central_nervous_system	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.25
p.S52L	CAMA-1	breast	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.25
p.K52N	HCT-15	large_intestine	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.25
p.T67N	DO2955	BRCA	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.2222

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Drug responses associated with INPP5J mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PRLALAPVG

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A	DEG_APCC_DBOX_1	55:63	PRLALAPVG	APC,CDC20,FZR1	0.9568	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRLALAPVG

Degron related mutations and impact score

Drug responses associated with INPP5J mutations

All proteins holding degron of PRLALAPVG