DegronMD

Uniprot ID: Q15735

Source protein: Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Source gene: INPP5J

Class: DEG_APCC_DBOX_1

Location: 55:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9568

ASA_SCORE: 77.9

COIL: 0.8707

CONS_SCORE: 0.2647

DSS_SCORE: 0.5126

HELIX: 0.0892

FCONS_SCORE: 1.0233

RIG_SCORE: 0.697

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T66N	TCGA-A8-A09A	BRCA	TCGA	PRLALAPVG	DEG_APCC_DBOX_1	0.25
p.T58N	TCGA-AJ-A3BH	UCEC	TCGA	PRLALAPVG	DEG_APCC_DBOX_1	0.7055
p.S53L	TCGA-CV-7104	HNSC	TCGA	PRLALAPVG	DEG_APCC_DBOX_1	0.2778
p.S53L	DO14798	HNSC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.2778
p.P70Q	TCGA-EE-A184	SKCM	TCGA	PRLALAPVG	DEG_APCC_DBOX_1	0.1389
p.T67N	DO2955	BRCA	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.2222
p.R46H	DO10276	COAD	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.1944
p.R46H	DO24120	LUAD	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.1944
p.R46H	SNU-407	large_intestine	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.1944
p.R63Q	DO20396	KIRC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.7329
p.R63Q	DO42977	UCEC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.7329
p.A53S	DO229015	LICA	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.2778
p.A53S	DO229027	LICA	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.2778
p.G56W	DO229027	LICA	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.7825
p.M68I	DO229032	LICA	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.1944
p.A70S	DO229036	LICA	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.1389
p.Q69K	DO23624	LUAD	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.1667
p.H73R	DO224563	LUSC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.0556
p.L48P	DO26641	LUSC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.1389
p.G57C	DO45462	LUSC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.76
p.P60S	DO37535	SKCM	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.6752
p.L68F	DO37406	SKCM	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.1944
p.P48S	DO223282	UCEC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.1389
p.S59N	DO41235	UCEC	ICGC	PRLALAPVG	DEG_APCC_DBOX_1	0.7069
p.R65Q	SIDM00410	Other Blood Cancers	GDSC	PRLALAPVG	DEG_APCC_DBOX_1	0.2778
p.R65Q	YT	haematopoietic_and_lymphoid_tissue	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.2778
p.P52S	SIDM01193	Glioma	GDSC	PRLALAPVG	DEG_APCC_DBOX_1	0.25
p.P52S	SIDM01768	Melanoma	GDSC	PRLALAPVG	DEG_APCC_DBOX_1	0.25
p.P52S	ACH-000040	Brain Cancer	CCLE	PRLALAPVG	DEG_APCC_DBOX_1	0.25
p.P52S	ACH-000899	Skin Cancer	CCLE	PRLALAPVG	DEG_APCC_DBOX_1	0.25
p.P52S	U-118-MG	central_nervous_system	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.25
p.D72N	ACH-002165	Skin Cancer	CCLE	PRLALAPVG	DEG_APCC_DBOX_1	0.0833
p.D72N	MZ2-MEL	skin	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.0833
p.S52L	CAMA-1	breast	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.25
p.V62E	SCC-4	upper_aerodigestive_tract	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.7693
p.K52N	HCT-15	large_intestine	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.25
p.D73N	MZ2-MEL	skin	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.0556
p.A67D	CCK-81	large_intestine	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.2222
p.Q70L	GP5d	large_intestine	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.1389
p.G55V	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.7532
p.S65G	OCUM-1	stomach	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.2778
p.R68M	DU-145	prostate	COSMIC	PRLALAPVG	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRLALAPVG

Degron related mutations and impact score

Drug responses associated with INPP5J mutations

All proteins holding degron of PRLALAPVG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A	DEG_APCC_DBOX_1	55:63	PRLALAPVG	APC,CDC20,FZR1	0.9568	More...