DegronMD

Uniprot ID: Q15735

Source protein: Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Source gene: INPP5J

Class: DEG_APCC_DBOX_1

Location: 82:90

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9983

ASA_SCORE: 76.7333

COIL: 0.8991

CONS_SCORE: 0.2649

DSS_SCORE: 0.523

HELIX: 0.0423

FCONS_SCORE: 1.0058

RIG_SCORE: 0.7195

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G87S	TCGA-A5-A0G2	UCEC	TCGA	PRPILAPLC	DEG_APCC_DBOX_1	0.6993
p.A92T	TCGA-AN-A0AK	BRCA	TCGA	PRPILAPLC	DEG_APCC_DBOX_1	0.2778
p.A92T	TCGA-EE-A3J5	SKCM	TCGA	PRPILAPLC	DEG_APCC_DBOX_1	0.2778
p.A92T	ACH-000967	Colon/Colorectal Cancer	CCLE	PRPILAPLC	DEG_APCC_DBOX_1	0.2778
p.A92T	ACH-001199	Colon/Colorectal Cancer	CCLE	PRPILAPLC	DEG_APCC_DBOX_1	0.2778
p.A92T	SNU-C2B	large_intestine	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	0.2778
p.T74I	TCGA-CQ-6222	HNSC	TCGA	PRPILAPLC	DEG_APCC_DBOX_1	0.1111
p.D86N	TCGA-CV-A45W	HNSC	TCGA	PRPILAPLC	DEG_APCC_DBOX_1	0.6932
p.D86N	DO52060	HNSC	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	0.6932
p.D86N	DO228947	LICA	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	0.6932
p.S85R	TCGA-G2-A3VY	BLCA	TCGA	PRPILAPLC	DEG_APCC_DBOX_1	0.7427
p.R100G	DO7780	COAD	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	0.0556
p.T99I	DO222849	COCA	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	0.0833
p.P75L	DO233791	GACA	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	0.1389
p.T75I	DO14433	HNSC	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	0.1389
p.A98S	DO228976	LICA	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	0.1111
p.A98S	DO229035	LICA	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	0.1111
p.A100S	DO229022	LICA	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	0.0556
p.R100S	DO229041	LICA	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	0.0556
p.A78S	DO229009	LICA	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	0.2222
p.H73R	DO224563	LUSC	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	0.0833
p.G94R	DO47268	SKCM	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	0.2222
p.E80K	DO37991	SKCM	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	0.2778
p.F97S	DO51776	STAD	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	0.1389
p.S81Y	DO41235	UCEC	ICGC	PRPILAPLC	DEG_APCC_DBOX_1	0.75
p.A98T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PRPILAPLC	DEG_APCC_DBOX_1	0.1111
p.A98T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PRPILAPLC	DEG_APCC_DBOX_1	0.1111
p.A98T	ACH-000995	Leukemia	CCLE	PRPILAPLC	DEG_APCC_DBOX_1	0.1111
p.A98T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	0.1111
p.A80V	SIDM00537	Colorectal Carcinoma	GDSC	PRPILAPLC	DEG_APCC_DBOX_1	0.2778
p.A80V	ACH-000982	Colon/Colorectal Cancer	CCLE	PRPILAPLC	DEG_APCC_DBOX_1	0.2778
p.A80V	ACH-001345	Colon/Colorectal Cancer	CCLE	PRPILAPLC	DEG_APCC_DBOX_1	0.2778
p.A80V	GP5d	large_intestine	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	0.2778
p.D72N	ACH-002165	Skin Cancer	CCLE	PRPILAPLC	DEG_APCC_DBOX_1	0.0556
p.D72N	MZ2-MEL	skin	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	0.0556
p.G97S	NCI-H1155	lung	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	0.1389
p.P84L	MCC13	skin	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	0.6471
p.A93T	SNU-C2B	large_intestine	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	0.25
p.D73N	MZ2-MEL	skin	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	0.0833
p.G95W	HEC-1	endometrium	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	0.1944
p.G94W	HEC-1	endometrium	COSMIC	PRPILAPLC	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRPILAPLC

Degron related mutations and impact score

Drug responses associated with INPP5J mutations

All proteins holding degron of PRPILAPLC

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A	DEG_APCC_DBOX_1	82:90	PRPILAPLC	APC,CDC20,FZR1	0.9983	More...