DegronMD

Uniprot ID: Q15735

Source protein: Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Source gene: INPP5J

Class: DEG_APCC_DBOX_1

Location: 14:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9962

ASA_SCORE: 70.4

COIL: 0.8314

CONS_SCORE: 0.2588

DSS_SCORE: 0.7594

HELIX: 0.054

FCONS_SCORE: 1.0466

RIG_SCORE: 0.599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A32V	TCGA-AU-6004	COAD	TCGA	TRAGLGSLP	DEG_APCC_DBOX_1	0.0556
p.A32V	DO7780	COAD	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	0.0556
p.S20Y	TCGA-QF-A5YS	UCEC	TCGA	TRAGLGSLP	DEG_APCC_DBOX_1	0.712
p.S20Y	DO52426	UCEC	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	0.712
p.L21F	DO222404	BTCA	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	0.6981
p.P19A	DO222404	BTCA	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	0.7503
p.R15K	DO219232	KIRC	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	0.7237
p.T5S	DO228985	LICA	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	0.1944
p.S10I	DO229006	LICA	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	0.2222
p.L18Q	DO50812	LICA	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	0.7765
p.R15S	DO24596	LUAD	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	0.7427
p.K10R	DO27461	LUSC	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	0.2222
p.P19L	DO220851	MELA	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	0.7582
p.A26T	DO232842	NACA	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	0.2222
p.A28S	DO47623	SKCM	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	0.1667
p.G12E	DO219468	SKCM	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	0.2778
p.G7V	DO41488	UCEC	ICGC	TRAGLGSLP	DEG_APCC_DBOX_1	0.1389
p.R15W	ACH-000622	Brain Cancer	CCLE	TRAGLGSLP	DEG_APCC_DBOX_1	0.8634
p.P7S	SW48	large_intestine	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	0.1389
p.G14D	COR-L321	NS	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	0.7198
p.A25T	SNU-C2B	large_intestine	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	0.25
p.D5N	MZ2-MEL	skin	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	0.1944
p.E14K	IPC-298	skin	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	0.7022
p.A31T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	0.0833
p.P21A	CS1	bone	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	0.7503
p.G27W	HEC-1	endometrium	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	0.1944
p.A13V	GP5d	large_intestine	COSMIC	TRAGLGSLP	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A	DEG_APCC_DBOX_1	14:22	TRAGLGSLP	APC,CDC20,FZR1	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRAGLGSLP

Degron related mutations and impact score

Drug responses associated with INPP5J mutations

All proteins holding degron of TRAGLGSLP