DegronMD

Uniprot ID: Q15735

Source protein: Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Source gene: INPP5J

Class: DEG_COP1_1

Location: 200:208

E3 ligase: COP1

DEGRON score: 0.9883

ASA_SCORE: 87.3444

COIL: 0.9651

CONS_SCORE: 0.2973

DSS_SCORE: 0.7434

HELIX: 0.0132

FCONS_SCORE: 1.1543

RIG_SCORE: 0.5673

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S208F	DO14158	HNSC	ICGC	STPSPVPSP	DEG_COP1_1	0.7982
p.A190S	DO228978	LICA	ICGC	STPSPVPSP	DEG_COP1_1	0.0556
p.L211S	DO50894	LICA	ICGC	STPSPVPSP	DEG_COP1_1	0.25
p.P199S	DO228014	SKCA	ICGC	STPSPVPSP	DEG_COP1_1	0.3056
p.Q203H	DO47278	SKCM	ICGC	STPSPVPSP	DEG_COP1_1	0.7582
p.S205L	DO37906	SKCM	ICGC	STPSPVPSP	DEG_COP1_1	0.7667
p.S205L	DO43041	UCEC	ICGC	STPSPVPSP	DEG_COP1_1	0.7667
p.A190V	DO43202	UCEC	ICGC	STPSPVPSP	DEG_COP1_1	0.0556
p.G197S	DO41235	UCEC	ICGC	STPSPVPSP	DEG_COP1_1	0.25
p.G218W	ACH-000945	Lung Cancer	CCLE	STPSPVPSP	DEG_COP1_1	0.0556
p.G218W	NCI-H650	lung	COSMIC	STPSPVPSP	DEG_COP1_1	0.0556
p.H196Y	ACH-000985	Colon/Colorectal Cancer	CCLE	STPSPVPSP	DEG_COP1_1	0.2222
p.H196Y	LS-411N	large_intestine	COSMIC	STPSPVPSP	DEG_COP1_1	0.2222
p.H197Y	LS-411N	large_intestine	COSMIC	STPSPVPSP	DEG_COP1_1	0.25
p.A209S	SJRH30	soft_tissue	COSMIC	STPSPVPSP	DEG_COP1_1	0.3056
p.R213H	NCI-H1155	lung	COSMIC	STPSPVPSP	DEG_COP1_1	0.1944
p.E214K	IPC-298	skin	COSMIC	STPSPVPSP	DEG_COP1_1	0.1667
p.P207S	SW48	large_intestine	COSMIC	STPSPVPSP	DEG_COP1_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A	DEG_COP1_1	200:208	STPSPVPSP	COP1	0.9883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons