DegronMD

Uniprot ID: Q15735

Source protein: Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Source gene: INPP5J

Class: DEG_SIAH_1

Location: 169:177

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.6676

ASA_SCORE: 88.6778

COIL: 0.9486

CONS_SCORE: 0.2613

DSS_SCORE: 0.7797

HELIX: 0.0272

FCONS_SCORE: 1.005

RIG_SCORE: 0.5809

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V175M	TCGA-06-2565	GBM	TCGA	EPPASVGPK	DEG_SIAH_1	0.7208
p.V175M	TCGA-C5-A7CJ	CESC	TCGA	EPPASVGPK	DEG_SIAH_1	0.7208
p.R162H	TCGA-AA-3663	COAD	TCGA	EPPASVGPK	DEG_SIAH_1	0.1389
p.R162H	TCGA-AA-A00N	COAD	TCGA	EPPASVGPK	DEG_SIAH_1	0.1389
p.R162H	TCGA-EO-A3B0	UCEC	TCGA	EPPASVGPK	DEG_SIAH_1	0.1389
p.V177M	TCGA-BG-A0M7	UCEC	TCGA	EPPASVGPK	DEG_SIAH_1	0.7208
p.V177M	RL95-2	endometrium	COSMIC	EPPASVGPK	DEG_SIAH_1	0.7208
p.R178H	TCGA-BR-8487	STAD	TCGA	EPPASVGPK	DEG_SIAH_1	0.3056
p.A180T	TCGA-CK-5913	COAD	TCGA	EPPASVGPK	DEG_SIAH_1	0.25
p.K172N	TCGA-EE-A3AC	SKCM	TCGA	EPPASVGPK	DEG_SIAH_1	0.6918
p.G173S	TCGA-FB-AAPQ	PAAD	TCGA	EPPASVGPK	DEG_SIAH_1	0.6993
p.Y187H	DO228246	BRCA	ICGC	EPPASVGPK	DEG_SIAH_1	0.0556
p.V176M	DO49886	CESC	ICGC	EPPASVGPK	DEG_SIAH_1	0.7208
p.V176M	DO12730	GBM	ICGC	EPPASVGPK	DEG_SIAH_1	0.7208
p.E169G	DO230311	COCA	ICGC	EPPASVGPK	DEG_SIAH_1	0.6087
p.R163C	DO227987	COCA	ICGC	EPPASVGPK	DEG_SIAH_1	0.1667
p.V178M	DO222765	COCA	ICGC	EPPASVGPK	DEG_SIAH_1	0.3056
p.V178M	DO42089	UCEC	ICGC	EPPASVGPK	DEG_SIAH_1	0.3056
p.V178M	RL95-2	endometrium	COSMIC	EPPASVGPK	DEG_SIAH_1	0.3056
p.S172R	DO11166	GBM	ICGC	EPPASVGPK	DEG_SIAH_1	0.7427
p.E174K	DO228963	LICA	ICGC	EPPASVGPK	DEG_SIAH_1	0.7022
p.G184V	DO222358	LICA	ICGC	EPPASVGPK	DEG_SIAH_1	0.1389
p.G181R	DO222647	MELA	ICGC	EPPASVGPK	DEG_SIAH_1	0.2222
p.G174S	DO218964	PAAD	ICGC	EPPASVGPK	DEG_SIAH_1	0.6993
p.Q168H	DO47337	SKCM	ICGC	EPPASVGPK	DEG_SIAH_1	0.3056
p.A182V	DO229234	THCA	ICGC	EPPASVGPK	DEG_SIAH_1	0.1944
p.V174M	SIDM00197	Ewing's Sarcoma	GDSC	EPPASVGPK	DEG_SIAH_1	0.7208
p.N171K	ACH-000065	Leukemia	CCLE	EPPASVGPK	DEG_SIAH_1	0.6918
p.N171K	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	EPPASVGPK	DEG_SIAH_1	0.6918
p.G164S	ACH-000980	Lung Cancer	CCLE	EPPASVGPK	DEG_SIAH_1	0.1944
p.G164S	NCI-H1155	lung	COSMIC	EPPASVGPK	DEG_SIAH_1	0.1944
p.G165S	NCI-H1155	lung	COSMIC	EPPASVGPK	DEG_SIAH_1	0.2222
p.R172C	SNU-175	large_intestine	COSMIC	EPPASVGPK	DEG_SIAH_1	0.8301
p.K170N	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	EPPASVGPK	DEG_SIAH_1	0.6918
p.A182S	NCI-H524	lung	COSMIC	EPPASVGPK	DEG_SIAH_1	0.1944
p.D163N	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	EPPASVGPK	DEG_SIAH_1	0.1667
p.Q187H	NCI-H2023	lung	COSMIC	EPPASVGPK	DEG_SIAH_1	0.0556
p.R169T	H513	pleura	COSMIC	EPPASVGPK	DEG_SIAH_1	0.7876
p.A181S	NCI-H524	lung	COSMIC	EPPASVGPK	DEG_SIAH_1	0.2222
p.N172K	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	EPPASVGPK	DEG_SIAH_1	0.6918

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EPPASVGPK

Degron related mutations and impact score

Drug responses associated with INPP5J mutations

All proteins holding degron of EPPASVGPK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A	DEG_SIAH_1	169:177	EPPASVGPK	SIAH1,SIAH2,SIAH3	0.6676	More...