DegronMD - Q5SZL2(CEP85L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P263S	TCGA-29-1711	OV	TCGA	DMTYSALP	CBL_PTK	253:260	Mutation substituting flanking lysine	0.3611
p.P263S	DO30630	OV	ICGC	DMTYSALP	CBL_PTK	253:260	Mutation substituting flanking lysine	0.3611
p.Q173H	TCGA-50-6595	LUAD	TCGA	SRNGLEKIG	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1667
p.Q173H	DO23654	LUAD	ICGC	SRNGLEKIG	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1667
p.T99A	TCGA-55-7995	LUAD	TCGA	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation altering degron motif	0.6028
p.T99A	DO45323	LUAD	ICGC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation altering degron motif	0.6028
p.S126L	TCGA-98-8021	LUSC	TCGA	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.25
p.S126L	DO27468	LUSC	ICGC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.25
p.K234T	TCGA-AJ-A3EL	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	242:246	Mutation rewiring degron network	0.1111
p.K234T	DO41542	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	242:246	Mutation rewiring degron network	0.1111
p.W128L	TCGA-AJ-A3EL	UCEC	TCGA	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1944
p.W128L	DO41542	UCEC	ICGC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1944
p.Q431H	TCGA-AP-A1DV	UCEC	TCGA	LQTPFSE	DEG_SCF_FBW7_2	427:433	Mutation altering degron motif	0.7582
p.Q431H	DO43186	UCEC	ICGC	LQTPFSE	DEG_SCF_FBW7_2	427:433	Mutation altering degron motif	0.7582
p.M269I	TCGA-AP-A1DV	UCEC	TCGA	DMTYSALP	CBL_PTK	253:260	Mutation rewiring degron network	0.0833
p.M269I	DO43186	UCEC	ICGC	DMTYSALP	CBL_PTK	253:260	Mutation rewiring degron network	0.0833
p.K188N	TCGA-AP-A1E0	UCEC	TCGA	SRNGLEKIG	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.3056
p.K188N	DO43154	UCEC	ICGC	SRNGLEKIG	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.3056
p.I189T	TCGA-CA-6717	COAD	TCGA	SRNGLEKIG	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.2778
p.I189T	DO8264	COAD	ICGC	SRNGLEKIG	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.2778
p.M133L	TCGA-CR-7364	HNSC	TCGA	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.0556
p.M133L	DO15679	HNSC	ICGC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.0556
p.T102A	TCGA-CV-7101	HNSC	TCGA	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation altering degron motif	0.7139
p.T102A	DO15310	HNSC	ICGC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation altering degron motif	0.7139
p.P101S	TCGA-CX-7086	HNSC	TCGA	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation altering degron motif	0.6752
p.P101S	DO15046	HNSC	ICGC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation altering degron motif	0.6752
p.S131R	TCGA-D7-5577	STAD	TCGA	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1111
p.S131R	DO38631	STAD	ICGC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1111
p.R252K	TCGA-E6-A1LX	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	242:246	Mutation rewiring degron network	0.1667
p.R252K	TCGA-E6-A1LX	UCEC	TCGA	DMTYSALP	CBL_PTK	253:260	Mutation rewiring degron network	0.3056
p.R252K	DO41020	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	242:246	Mutation rewiring degron network	0.1667
p.R252K	DO41020	UCEC	ICGC	DMTYSALP	CBL_PTK	253:260	Mutation rewiring degron network	0.3056
p.R183M	TCGA-EO-A22X	UCEC	TCGA	SRNGLEKIG	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.8632
p.R183M	DO43907	UCEC	ICGC	SRNGLEKIG	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.8632
p.D256Y	TCGA-EO-A3B0	UCEC	TCGA	DMTYSALP	CBL_PTK	253:260	Mutation altering degron motif	0.7325
p.D256Y	DO219773	UCEC	ICGC	DMTYSALP	CBL_PTK	253:260	Mutation altering degron motif	0.7325
p.V105L	TCGA-K7-A6G5	LIHC	TCGA	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation altering degron motif	0.6765
p.V105L	DO48602	LIHC	ICGC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation altering degron motif	0.6765
p.L117R	TCGA-VS-A9V4	CESC	TCGA	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation blocking phosphorylation signal	0.75
p.L117R	DO219744	CESC	ICGC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation blocking phosphorylation signal	0.75
p.L117R	SIDM00118	Colorectal Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation blocking phosphorylation signal	0.75
p.L117R	ACH-001081	Colon/Colorectal Cancer	CCLE	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation blocking phosphorylation signal	0.75
p.L117R	HCC2998	large intestine	COSMIC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation blocking phosphorylation signal	0.75
p.G190E	TCGA-WE-A8K6	SKCM	TCGA	SRNGLEKIG	DEG_APCC_DBOX_1	179:187	Mutation blocking ubiquitination signal	0.6944
p.G190E	DO51283	SKCM	ICGC	SRNGLEKIG	DEG_APCC_DBOX_1	179:187	Mutation blocking ubiquitination signal	0.6944
p.A419V	TCGA-XK-AAIW	PRAD	TCGA	LQTPFSE	DEG_SCF_FBW7_2	427:433	Mutation rewiring degron network	0.1111
p.A419V	DO51407	PRAD	ICGC	LQTPFSE	DEG_SCF_FBW7_2	427:433	Mutation rewiring degron network	0.1111
p.A419V	SIDM01617	Endometrial Carcinoma	GDSC	LQTPFSE	DEG_SCF_FBW7_2	427:433	Mutation rewiring degron network	0.1111
p.A419V	ACH-000994	Endometrial/Uterine Cancer	CCLE	LQTPFSE	DEG_SCF_FBW7_2	427:433	Mutation rewiring degron network	0.1111
p.A112T	DO225213	BRCA	ICGC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1667
p.A112T	DO225213	BRCA	ICGC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation rewiring degron network	0.1389
p.A112T	DO227529	BRCA	ICGC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1667
p.A112T	DO227529	BRCA	ICGC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation rewiring degron network	0.1389
p.P254T	DO229010	COCA	ICGC	DMTYSALP	CBL_PTK	253:260	Mutation altering degron motif	0.7031
p.P254T	DO229013	COCA	ICGC	DMTYSALP	CBL_PTK	253:260	Mutation altering degron motif	0.7031
p.P254T	DO229016	COCA	ICGC	DMTYSALP	CBL_PTK	253:260	Mutation altering degron motif	0.7031
p.P254T	DO229005	COCA	ICGC	DMTYSALP	CBL_PTK	253:260	Mutation altering degron motif	0.7031
p.P254T	DO229353	LAML	ICGC	DMTYSALP	CBL_PTK	253:260	Mutation altering degron motif	0.7031
p.P254T	DO229505	LAML	ICGC	DMTYSALP	CBL_PTK	253:260	Mutation altering degron motif	0.7031
p.P254T	DO228947	LICA	ICGC	DMTYSALP	CBL_PTK	253:260	Mutation altering degron motif	0.7031
p.P254T	DO230529	LUSC	ICGC	DMTYSALP	CBL_PTK	253:260	Mutation altering degron motif	0.7031
p.R244K	DO228944	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	242:246	Mutation altering degron motif	0.7237
p.L430I	DO228952	LICA	ICGC	LQTPFSE	DEG_SCF_FBW7_2	427:433	Mutation altering degron motif	0.7174
p.Q253H	DO228960	LICA	ICGC	DMTYSALP	CBL_PTK	253:260	Mutation altering degron motif	0.7582
p.H441N	DO229022	LICA	ICGC	LQTPFSE	DEG_SCF_FBW7_2	427:433	Mutation rewiring degron network	0.1111
p.Q422K	DO229027	LICA	ICGC	LQTPFSE	DEG_SCF_FBW7_2	427:433	Mutation rewiring degron network	0.1944
p.T432K	DO229031	LICA	ICGC	LQTPFSE	DEG_SCF_FBW7_2	427:433	Mutation altering degron motif	0.7306
p.A194D	DO229045	LICA	ICGC	SRNGLEKIG	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1389
p.S111R	DO229009	LICA	ICGC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.S111R	DO229009	LICA	ICGC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation rewiring degron network	0.1667
p.S129N	DO23290	LINC	ICGC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1667
p.D242E	DO23310	LINC	ICGC	ASSST	DEG_SPOP_SBC_1	242:246	Mutation altering degron motif	0.6758
p.S115F	DO222644	MELA	ICGC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.25
p.S115F	DO222644	MELA	ICGC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation rewiring degron network	0.0556
p.R251K	DO222843	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	242:246	Mutation rewiring degron network	0.1944
p.R251K	DO222843	MELA	ICGC	DMTYSALP	CBL_PTK	253:260	Mutation rewiring degron network	0.2778
p.M257T	DO36556	READ	ICGC	DMTYSALP	CBL_PTK	253:260	Mutation altering degron motif	0.7423
p.T130A	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.T130A	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.T130A	SIDM00705	Non-Cancerous	GDSC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.T130A	SIDM00393	Gastric Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.T130A	SIDM00690	Head and Neck Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.T130A	SIDM00210	Ovarian Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.T130A	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.T130A	SIDM00706	Small Cell Lung Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.T130A	SIDM01133	Other Solid Cancers	GDSC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.T130A	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.T130A	SIDM00479	Esophageal Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.T130A	SIDM01173	Rhabdomyosarcoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.T130A	SIDM01409	Bladder Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.T130A	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.P107L	SIDM01126	Small Cell Lung Carcinoma	GDSC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation rewiring degron network	0.2778
p.P107L	SIDM01112	Osteosarcoma	GDSC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation rewiring degron network	0.2778
p.P107L	SIDM00257	Neuroblastoma	GDSC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation rewiring degron network	0.2778
p.P93A	SIDM00383	Gastric Carcinoma	GDSC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation rewiring degron network	0.2222
p.P93A	ACH-002198	Gastric Cancer	CCLE	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation rewiring degron network	0.2222
p.P93A	SCH	stomach	COSMIC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation rewiring degron network	0.2222
p.D256N	SIDM00849	Kidney Carcinoma	GDSC	DMTYSALP	CBL_PTK	253:260	Mutation altering degron motif	0.6932
p.D256N	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DMTYSALP	CBL_PTK	253:260	Mutation altering degron motif	0.6932
p.P433S	SIDM00006	Other Solid Cancers	GDSC	LQTPFSE	DEG_SCF_FBW7_2	427:433	Mutation altering degron motif	0.6752
p.P433S	ACH-001552	Skin Cancer	CCLE	LQTPFSE	DEG_SCF_FBW7_2	427:433	Mutation altering degron motif	0.6752
p.P433S	MCC26	skin	COSMIC	LQTPFSE	DEG_SCF_FBW7_2	427:433	Mutation altering degron motif	0.6752
p.L100V	SIDM00006	Other Solid Cancers	GDSC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation altering degron motif	0.6765
p.L100V	ACH-001552	Skin Cancer	CCLE	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation altering degron motif	0.6765
p.L100V	MCC26	skin	COSMIC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation altering degron motif	0.6765
p.V255I	SIDM00850	Gastric Carcinoma	GDSC	DMTYSALP	CBL_PTK	253:260	Mutation altering degron motif	0.7076
p.V255I	AGS	stomach	COSMIC	DMTYSALP	CBL_PTK	253:260	Mutation altering degron motif	0.7076
p.S108P	SIDM01618	B-Lymphoblastic Leukemia	GDSC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.0556
p.S108P	SIDM01618	B-Lymphoblastic Leukemia	GDSC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation rewiring degron network	0.25
p.S108P	ACH-000942	Leukemia	CCLE	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.0556
p.S108P	ACH-000942	Leukemia	CCLE	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation rewiring degron network	0.25
p.W128G	ACH-001494	Bile Duct Cancer	CCLE	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1944
p.W128G	EGI-1	biliary tract	COSMIC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1944
p.P90A	SCH	stomach	COSMIC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation rewiring degron network	0.1389
p.E115G	SNU-175	large intestine	COSMIC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.25
p.E115G	SNU-175	large intestine	COSMIC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation rewiring degron network	0.0556
p.P430S	MCC26	skin	COSMIC	LQTPFSE	DEG_SCF_FBW7_2	427:433	Mutation altering degron motif	0.6752
p.W125G	EGI-1	biliary tract	COSMIC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.2778
p.V252I	AGS	stomach	COSMIC	ASSST	DEG_SPOP_SBC_1	242:246	Mutation rewiring degron network	0.1667
p.V252I	AGS	stomach	COSMIC	DMTYSALP	CBL_PTK	253:260	Mutation rewiring degron network	0.3056
p.L97V	MCC26	skin	COSMIC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation altering degron motif	0.5654
p.Q180K	LB771-HNC	upper aerodigestive tract	COSMIC	SRNGLEKIG	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.6944
p.L114R	HCC2998	large intestine	COSMIC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.2222
p.L114R	HCC2998	large intestine	COSMIC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation rewiring degron network	0.0833
p.D113E	SBC-5	lung	COSMIC	LTPDGS	DEG_SCF_FBW7_1	118:123	Mutation blocking ubiquitination signal	0.6389
p.D113E	SBC-5	lung	COSMIC	LPTAHVMPS	DEG_SIAH_1	97:105	Mutation blocking ubiquitination signal	0.5556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP85L

UniProt ID: Q5SZL2

Entrez ID: 387119

Protein name: Centrosomal protein of 85 kDa-like (Serologically defined breast cancer antigen NY-BR-15)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEP85L in