DegronMD

Uniprot ID: Q5SZL2

Source protein: Centrosomal protein of 85 kDa-like

Source gene: CEP85L

Class: DEG_APCC_DBOX_1

Location: 179:187

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.97

ASA_SCORE: 73.4

COIL: 0.6272

CONS_SCORE: 0.3136

DSS_SCORE: 0.4207

HELIX: 0.2664

FCONS_SCORE: 1.3692

RIG_SCORE: 0.7435

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q173H	TCGA-50-6595	LUAD	TCGA	SRNGLEKIG	DEG_APCC_DBOX_1	0.1667
p.Q173H	DO23654	LUAD	ICGC	SRNGLEKIG	DEG_APCC_DBOX_1	0.1667
p.K188N	TCGA-AP-A1E0	UCEC	TCGA	SRNGLEKIG	DEG_APCC_DBOX_1	0.3056
p.K188N	DO43154	UCEC	ICGC	SRNGLEKIG	DEG_APCC_DBOX_1	0.3056
p.I189T	TCGA-CA-6717	COAD	TCGA	SRNGLEKIG	DEG_APCC_DBOX_1	0.2778
p.I189T	DO8264	COAD	ICGC	SRNGLEKIG	DEG_APCC_DBOX_1	0.2778
p.R183M	TCGA-EO-A22X	UCEC	TCGA	SRNGLEKIG	DEG_APCC_DBOX_1	0.8632
p.R183M	DO43907	UCEC	ICGC	SRNGLEKIG	DEG_APCC_DBOX_1	0.8632
p.G190E	TCGA-WE-A8K6	SKCM	TCGA	SRNGLEKIG	DEG_APCC_DBOX_1	0.6944
p.G190E	DO51283	SKCM	ICGC	SRNGLEKIG	DEG_APCC_DBOX_1	0.6944
p.A194D	DO229045	LICA	ICGC	SRNGLEKIG	DEG_APCC_DBOX_1	0.1389
p.Q180K	LB771-HNC	upper_aerodigestive_tract	COSMIC	SRNGLEKIG	DEG_APCC_DBOX_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SZL2	Centrosomal protein of 85 kDa-like	DEG_APCC_DBOX_1	179:187	SRNGLEKIG	APC,CDC20,FZR1	0.97	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons