DegronMD

Uniprot ID: Q5SZL2

Source protein: Centrosomal protein of 85 kDa-like

Source gene: CEP85L

Class: DEG_SCF_FBW7_1

Location: 118:123

E3 ligase: FBXW7

DEGRON score: 0.9854

ASA_SCORE: 72.2833

COIL: 0.8692

CONS_SCORE: 0.2724

DSS_SCORE: 0.494

HELIX: 0.087

FCONS_SCORE: 0.9462

RIG_SCORE: 0.6356

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S126L	TCGA-98-8021	LUSC	TCGA	LTPDGS	DEG_SCF_FBW7_1	0.25
p.S126L	DO27468	LUSC	ICGC	LTPDGS	DEG_SCF_FBW7_1	0.25
p.W128L	TCGA-AJ-A3EL	UCEC	TCGA	LTPDGS	DEG_SCF_FBW7_1	0.1944
p.W128L	DO41542	UCEC	ICGC	LTPDGS	DEG_SCF_FBW7_1	0.1944
p.M133L	TCGA-CR-7364	HNSC	TCGA	LTPDGS	DEG_SCF_FBW7_1	0.0556
p.M133L	DO15679	HNSC	ICGC	LTPDGS	DEG_SCF_FBW7_1	0.0556
p.S131R	TCGA-D7-5577	STAD	TCGA	LTPDGS	DEG_SCF_FBW7_1	0.1111
p.S131R	DO38631	STAD	ICGC	LTPDGS	DEG_SCF_FBW7_1	0.1111
p.L117R	TCGA-VS-A9V4	CESC	TCGA	LTPDGS	DEG_SCF_FBW7_1	0.75
p.L117R	DO219744	CESC	ICGC	LTPDGS	DEG_SCF_FBW7_1	0.75
p.L117R	SIDM00118	Colorectal Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	0.75
p.L117R	ACH-001081	Colon/Colorectal Cancer	CCLE	LTPDGS	DEG_SCF_FBW7_1	0.75
p.L117R	HCC2998	large_intestine	COSMIC	LTPDGS	DEG_SCF_FBW7_1	0.75
p.A112T	DO225213	BRCA	ICGC	LTPDGS	DEG_SCF_FBW7_1	0.1667
p.A112T	DO227529	BRCA	ICGC	LTPDGS	DEG_SCF_FBW7_1	0.1667
p.S111R	DO229009	LICA	ICGC	LTPDGS	DEG_SCF_FBW7_1	0.1389
p.S129N	DO23290	LINC	ICGC	LTPDGS	DEG_SCF_FBW7_1	0.1667
p.S115F	DO222644	MELA	ICGC	LTPDGS	DEG_SCF_FBW7_1	0.25
p.T130A	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	0.1389
p.T130A	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	0.1389
p.T130A	SIDM00705	Non-Cancerous	GDSC	LTPDGS	DEG_SCF_FBW7_1	0.1389
p.T130A	SIDM00393	Gastric Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	0.1389
p.T130A	SIDM00690	Head and Neck Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	0.1389
p.T130A	SIDM00210	Ovarian Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	0.1389
p.T130A	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	0.1389
p.T130A	SIDM00706	Small Cell Lung Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	0.1389
p.T130A	SIDM01133	Other Solid Cancers	GDSC	LTPDGS	DEG_SCF_FBW7_1	0.1389
p.T130A	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	0.1389
p.T130A	SIDM00479	Esophageal Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	0.1389
p.T130A	SIDM01173	Rhabdomyosarcoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	0.1389
p.T130A	SIDM01409	Bladder Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	0.1389
p.T130A	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LTPDGS	DEG_SCF_FBW7_1	0.1389
p.S108P	SIDM01618	B-Lymphoblastic Leukemia	GDSC	LTPDGS	DEG_SCF_FBW7_1	0.0556
p.S108P	ACH-000942	Leukemia	CCLE	LTPDGS	DEG_SCF_FBW7_1	0.0556
p.W128G	ACH-001494	Bile Duct Cancer	CCLE	LTPDGS	DEG_SCF_FBW7_1	0.1944
p.W128G	EGI-1	biliary_tract	COSMIC	LTPDGS	DEG_SCF_FBW7_1	0.1944
p.E115G	SNU-175	large_intestine	COSMIC	LTPDGS	DEG_SCF_FBW7_1	0.25
p.W125G	EGI-1	biliary_tract	COSMIC	LTPDGS	DEG_SCF_FBW7_1	0.2778
p.L114R	HCC2998	large_intestine	COSMIC	LTPDGS	DEG_SCF_FBW7_1	0.2222
p.D113E	SBC-5	lung	COSMIC	LTPDGS	DEG_SCF_FBW7_1	0.6389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPDGS

Degron related mutations and impact score

Drug responses associated with CEP85L mutations

All proteins holding degron of LTPDGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SZL2	Centrosomal protein of 85 kDa-like	DEG_SCF_FBW7_1	118:123	LTPDGS	FBXW7	0.9854	More...