DegronMD

Uniprot ID: Q5SZL2

Source protein: Centrosomal protein of 85 kDa-like

Source gene: CEP85L

Class: DEG_SIAH_1

Location: 97:105

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.97

ASA_SCORE: 58.1556

COIL: 0.772

CONS_SCORE: 0.3122

DSS_SCORE: 0.4664

HELIX: 0.0433

FCONS_SCORE: 1.0929

RIG_SCORE: 0.716

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T99A	TCGA-55-7995	LUAD	TCGA	LPTAHVMPS	DEG_SIAH_1	0.6028
p.T99A	DO45323	LUAD	ICGC	LPTAHVMPS	DEG_SIAH_1	0.6028
p.T102A	TCGA-CV-7101	HNSC	TCGA	LPTAHVMPS	DEG_SIAH_1	0.7139
p.T102A	DO15310	HNSC	ICGC	LPTAHVMPS	DEG_SIAH_1	0.7139
p.P101S	TCGA-CX-7086	HNSC	TCGA	LPTAHVMPS	DEG_SIAH_1	0.6752
p.P101S	DO15046	HNSC	ICGC	LPTAHVMPS	DEG_SIAH_1	0.6752
p.V105L	TCGA-K7-A6G5	LIHC	TCGA	LPTAHVMPS	DEG_SIAH_1	0.6765
p.V105L	DO48602	LIHC	ICGC	LPTAHVMPS	DEG_SIAH_1	0.6765
p.A112T	DO225213	BRCA	ICGC	LPTAHVMPS	DEG_SIAH_1	0.1389
p.A112T	DO227529	BRCA	ICGC	LPTAHVMPS	DEG_SIAH_1	0.1389
p.S111R	DO229009	LICA	ICGC	LPTAHVMPS	DEG_SIAH_1	0.1667
p.S115F	DO222644	MELA	ICGC	LPTAHVMPS	DEG_SIAH_1	0.0556
p.P107L	SIDM01126	Small Cell Lung Carcinoma	GDSC	LPTAHVMPS	DEG_SIAH_1	0.2778
p.P107L	SIDM01112	Osteosarcoma	GDSC	LPTAHVMPS	DEG_SIAH_1	0.2778
p.P107L	SIDM00257	Neuroblastoma	GDSC	LPTAHVMPS	DEG_SIAH_1	0.2778
p.P93A	SIDM00383	Gastric Carcinoma	GDSC	LPTAHVMPS	DEG_SIAH_1	0.2222
p.P93A	ACH-002198	Gastric Cancer	CCLE	LPTAHVMPS	DEG_SIAH_1	0.2222
p.P93A	SCH	stomach	COSMIC	LPTAHVMPS	DEG_SIAH_1	0.2222
p.L100V	SIDM00006	Other Solid Cancers	GDSC	LPTAHVMPS	DEG_SIAH_1	0.6765
p.L100V	ACH-001552	Skin Cancer	CCLE	LPTAHVMPS	DEG_SIAH_1	0.6765
p.L100V	MCC26	skin	COSMIC	LPTAHVMPS	DEG_SIAH_1	0.6765
p.S108P	SIDM01618	B-Lymphoblastic Leukemia	GDSC	LPTAHVMPS	DEG_SIAH_1	0.25
p.S108P	ACH-000942	Leukemia	CCLE	LPTAHVMPS	DEG_SIAH_1	0.25
p.P90A	SCH	stomach	COSMIC	LPTAHVMPS	DEG_SIAH_1	0.1389
p.E115G	SNU-175	large_intestine	COSMIC	LPTAHVMPS	DEG_SIAH_1	0.0556
p.L97V	MCC26	skin	COSMIC	LPTAHVMPS	DEG_SIAH_1	0.5654
p.L114R	HCC2998	large_intestine	COSMIC	LPTAHVMPS	DEG_SIAH_1	0.0833
p.D113E	SBC-5	lung	COSMIC	LPTAHVMPS	DEG_SIAH_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SZL2	Centrosomal protein of 85 kDa-like	DEG_SIAH_1	97:105	LPTAHVMPS	SIAH1,SIAH2,SIAH3	0.97	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPTAHVMPS

Degron related mutations and impact score

Drug responses associated with CEP85L mutations

All proteins holding degron of LPTAHVMPS