DegronMD

Uniprot ID: Q5SZL2

Source protein: Centrosomal protein of 85 kDa-like

Source gene: CEP85L

Class: DEG_SCF_FBW7_2

Location: 427:433

E3 ligase: FBXW7

DEGRON score: 0.8178

ASA_SCORE: 97.4857

COIL: 0.6051

CONS_SCORE: 0.354

DSS_SCORE: 0.573

HELIX: 0.3647

FCONS_SCORE: 1.0149

RIG_SCORE: 0.6876

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q431H	TCGA-AP-A1DV	UCEC	TCGA	LQTPFSE	DEG_SCF_FBW7_2	0.7582
p.Q431H	DO43186	UCEC	ICGC	LQTPFSE	DEG_SCF_FBW7_2	0.7582
p.A419V	TCGA-XK-AAIW	PRAD	TCGA	LQTPFSE	DEG_SCF_FBW7_2	0.1111
p.A419V	DO51407	PRAD	ICGC	LQTPFSE	DEG_SCF_FBW7_2	0.1111
p.A419V	SIDM01617	Endometrial Carcinoma	GDSC	LQTPFSE	DEG_SCF_FBW7_2	0.1111
p.A419V	ACH-000994	Endometrial/Uterine Cancer	CCLE	LQTPFSE	DEG_SCF_FBW7_2	0.1111
p.L430I	DO228952	LICA	ICGC	LQTPFSE	DEG_SCF_FBW7_2	0.7174
p.H441N	DO229022	LICA	ICGC	LQTPFSE	DEG_SCF_FBW7_2	0.1111
p.Q422K	DO229027	LICA	ICGC	LQTPFSE	DEG_SCF_FBW7_2	0.1944
p.T432K	DO229031	LICA	ICGC	LQTPFSE	DEG_SCF_FBW7_2	0.7306
p.P433S	SIDM00006	Other Solid Cancers	GDSC	LQTPFSE	DEG_SCF_FBW7_2	0.6752
p.P433S	ACH-001552	Skin Cancer	CCLE	LQTPFSE	DEG_SCF_FBW7_2	0.6752
p.P433S	MCC26	skin	COSMIC	LQTPFSE	DEG_SCF_FBW7_2	0.6752
p.P430S	MCC26	skin	COSMIC	LQTPFSE	DEG_SCF_FBW7_2	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SZL2	Centrosomal protein of 85 kDa-like	DEG_SCF_FBW7_2	427:433	LQTPFSE	FBXW7	0.8178	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons