DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
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Degron:
DMTYSALP
Uniprot ID:
Q5SZL2
Source protein:
Centrosomal protein of 85 kDa-like
Source gene:
CEP85L
Class:
CBL_PTK
Location:
253:260
E3 ligase:
CBL
DEGRON score:
0.9992
ASA_SCORE:
72.3
COIL:
0.762
CONS_SCORE:
0.3957
DSS_SCORE:
0.4815
HELIX:
0.1823
FCONS_SCORE:
1.1708
RIG_SCORE:
0.7253
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P263S
TCGA-29-1711
OV
TCGA
DMTYSALP
CBL_PTK
0.3611
p.P263S
DO30630
OV
ICGC
DMTYSALP
CBL_PTK
0.3611
p.M269I
TCGA-AP-A1DV
UCEC
TCGA
DMTYSALP
CBL_PTK
0.0833
p.M269I
DO43186
UCEC
ICGC
DMTYSALP
CBL_PTK
0.0833
p.R252K
TCGA-E6-A1LX
UCEC
TCGA
DMTYSALP
CBL_PTK
0.3056
p.R252K
DO41020
UCEC
ICGC
DMTYSALP
CBL_PTK
0.3056
p.D256Y
TCGA-EO-A3B0
UCEC
TCGA
DMTYSALP
CBL_PTK
0.7325
p.D256Y
DO219773
UCEC
ICGC
DMTYSALP
CBL_PTK
0.7325
p.P254T
DO229010
COCA
ICGC
DMTYSALP
CBL_PTK
0.7031
p.P254T
DO229013
COCA
ICGC
DMTYSALP
CBL_PTK
0.7031
p.P254T
DO229016
COCA
ICGC
DMTYSALP
CBL_PTK
0.7031
p.P254T
DO229005
COCA
ICGC
DMTYSALP
CBL_PTK
0.7031
p.P254T
DO229353
LAML
ICGC
DMTYSALP
CBL_PTK
0.7031
p.P254T
DO229505
LAML
ICGC
DMTYSALP
CBL_PTK
0.7031
p.P254T
DO228947
LICA
ICGC
DMTYSALP
CBL_PTK
0.7031
p.P254T
DO230529
LUSC
ICGC
DMTYSALP
CBL_PTK
0.7031
p.Q253H
DO228960
LICA
ICGC
DMTYSALP
CBL_PTK
0.7582
p.R251K
DO222843
MELA
ICGC
DMTYSALP
CBL_PTK
0.2778
p.M257T
DO36556
READ
ICGC
DMTYSALP
CBL_PTK
0.7423
p.D256N
SIDM00849
Kidney Carcinoma
GDSC
DMTYSALP
CBL_PTK
0.6932
p.D256N
SIDM00431
T-Lymphoblastic Leukemia
GDSC
DMTYSALP
CBL_PTK
0.6932
p.V255I
SIDM00850
Gastric Carcinoma
GDSC
DMTYSALP
CBL_PTK
0.7076
p.V255I
AGS
stomach
COSMIC
DMTYSALP
CBL_PTK
0.7076
p.V252I
AGS
stomach
COSMIC
DMTYSALP
CBL_PTK
0.3056
Drug responses associated with CEP85L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DMTYSALP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5SZL2
Centrosomal protein of 85 kDa-like
CBL_PTK
253:260
DMTYSALP
CBL
0.9992
More...