DegronMD - Q9Y561(LRP12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A687V	TCGA-19-5956	GBM	TCGA	ASSST	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.1667
p.A687V	TCGA-AX-A0J1	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.1667
p.A687V	TCGA-XK-AAIW	PRAD	TCGA	ASSST	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.1667
p.R701L	TCGA-22-4593	LUSC	TCGA	ASSST	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.2222
p.T683M	TCGA-A7-A0CJ	BRCA	TCGA	ASSST	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.0556
p.T683M	ACH-001394	Breast Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.0556
p.A691T	TCGA-XK-AAIW	PRAD	TCGA	ASSST	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.2778
p.T693I	DO234373	ESAD	ICGC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.7078
p.D691Y	DO24900	LUAD	ICGC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.2778
p.P697L	DO51493	PACA	ICGC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.7582
p.R704C	DO41871	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.1389
p.R704C	DO42713	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.1389
p.G702C	DO229542	UTCA	ICGC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.1944
p.S694G	SIDM00656	Burkitt's Lymphoma	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.5882
p.S694G	SIDM00200	Ewing's Sarcoma	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.5882
p.S694G	SIDM01112	Osteosarcoma	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.5882
p.S694G	SIDM00650	Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.5882
p.S694G	SIDM00694	Other Solid Cancers	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.5882
p.S694G	SIDM00878	Breast Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.5882
p.S694G	SIDM00849	Kidney Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.5882
p.S694G	SIDM00493	Other Solid Cancers	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.5882
p.S694G	SIDM00793	Burkitt's Lymphoma	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.5882
p.S694G	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.5882
p.S694G	SIDM00954	Breast Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.5882
p.S694G	SIDM00431	T-Lymphoblastic Leukemia	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.5882
p.S694G	SIDM00863	Burkitt's Lymphoma	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.5882
p.S694G	SIDM01681	Non-Cancerous	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.5882
p.S694G	SIDM00628	Breast Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.5882
p.S694G	SIDM01318	Hepatocellular Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.5882
p.S694G	SIDM00641	Burkitt's Lymphoma	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.5882
p.A693T	SIDM00282	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.7139
p.A693T	ACH-000998	Colon/Colorectal Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.7139
p.A693T	CW-2	large intestine	COSMIC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.7139
p.S694C	KYSE-270	oesophagus	COSMIC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.643
p.Q706P	D-247MG	central nervous system	COSMIC	ASSST	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.0833

Kaplan plot for LRP12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRP12

UniProt ID: Q9Y561

Entrez ID: 29967

Protein name: Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRP12 in