DegronMD

Uniprot ID: Q9Y561

Source protein: Low-density lipoprotein receptor-related protein 12

Source gene: LRP12

Class: DEG_SPOP_SBC_1

Location: 693:697

E3 ligase: SPOP

DEGRON score: 0.9867

ASA_SCORE: 75.3

COIL: 0.866

CONS_SCORE: 0.5143

DSS_SCORE: 0.5638

HELIX: 0.106

FCONS_SCORE: 0.8308

RIG_SCORE: 0.6513

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A687V	TCGA-19-5956	GBM	TCGA	ASSST	DEG_SPOP_SBC_1	0.1667
p.A687V	TCGA-AX-A0J1	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	0.1667
p.A687V	TCGA-XK-AAIW	PRAD	TCGA	ASSST	DEG_SPOP_SBC_1	0.1667
p.R701L	TCGA-22-4593	LUSC	TCGA	ASSST	DEG_SPOP_SBC_1	0.2222
p.T683M	TCGA-A7-A0CJ	BRCA	TCGA	ASSST	DEG_SPOP_SBC_1	0.0556
p.T683M	ACH-001394	Breast Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	0.0556
p.A691T	TCGA-XK-AAIW	PRAD	TCGA	ASSST	DEG_SPOP_SBC_1	0.2778
p.T693I	DO234373	ESAD	ICGC	ASSST	DEG_SPOP_SBC_1	0.7078
p.D691Y	DO24900	LUAD	ICGC	ASSST	DEG_SPOP_SBC_1	0.2778
p.P697L	DO51493	PACA	ICGC	ASSST	DEG_SPOP_SBC_1	0.7582
p.R704C	DO41871	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	0.1389
p.R704C	DO42713	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	0.1389
p.G702C	DO229542	UTCA	ICGC	ASSST	DEG_SPOP_SBC_1	0.1944
p.S694G	SIDM00656	Burkitt's Lymphoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.5882
p.S694G	SIDM00200	Ewing's Sarcoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.5882
p.S694G	SIDM01112	Osteosarcoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.5882
p.S694G	SIDM00650	Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.5882
p.S694G	SIDM00694	Other Solid Cancers	GDSC	ASSST	DEG_SPOP_SBC_1	0.5882
p.S694G	SIDM00878	Breast Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.5882
p.S694G	SIDM00849	Kidney Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.5882
p.S694G	SIDM00493	Other Solid Cancers	GDSC	ASSST	DEG_SPOP_SBC_1	0.5882
p.S694G	SIDM00793	Burkitt's Lymphoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.5882
p.S694G	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.5882
p.S694G	SIDM00954	Breast Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.5882
p.S694G	SIDM00431	T-Lymphoblastic Leukemia	GDSC	ASSST	DEG_SPOP_SBC_1	0.5882
p.S694G	SIDM00863	Burkitt's Lymphoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.5882
p.S694G	SIDM01681	Non-Cancerous	GDSC	ASSST	DEG_SPOP_SBC_1	0.5882
p.S694G	SIDM00628	Breast Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.5882
p.S694G	SIDM01318	Hepatocellular Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.5882
p.S694G	SIDM00641	Burkitt's Lymphoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.5882
p.A693T	SIDM00282	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.7139
p.A693T	ACH-000998	Colon/Colorectal Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	0.7139
p.A693T	CW-2	large_intestine	COSMIC	ASSST	DEG_SPOP_SBC_1	0.7139
p.S694C	KYSE-270	oesophagus	COSMIC	ASSST	DEG_SPOP_SBC_1	0.643
p.Q706P	D-247MG	central_nervous_system	COSMIC	ASSST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	DEG_SPOP_SBC_1	934:938	ASSST	SPOP	0.9942	More...
O00444	Serine/threonine-protein kinase PLK4	DEG_SPOP_SBC_1	296:300	ASSST	SPOP	0.9834	More...
O15085	Rho guanine nucleotide exchange factor 11	DEG_SPOP_SBC_1	652:656	ASSST	SPOP	0.9992	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	695:699	ASSST	SPOP	0.9867	More...
O43719	HIV Tat-specific factor 1	DEG_SPOP_SBC_1	82:86	ASSST	SPOP	0.9934	More...
O95171	Sciellin	DEG_SPOP_SBC_1	173:177	ASSST	SPOP	0.8889	More...
O95935	T-box transcription factor TBX18	DEG_SPOP_SBC_1	369:373	ASSST	SPOP	0.8014	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	3090:3094	ASSST	SPOP	0.9844	More...
P23771	Trans-acting T-cell-specific transcription factor GATA-3	DEG_SPOP_SBC_1	211:215	ASSST	SPOP	0.6066	More...
P37088	Amiloride-sensitive sodium channel subunit alpha	DEG_SPOP_SBC_1	659:663	ASSST	SPOP	0.9733	More...
P43115	Prostaglandin E2 receptor EP3 subtype	DEG_SPOP_SBC_1	368:372	ASSST	SPOP	0.5018	More...
P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	DEG_SPOP_SBC_1	359:363	ASSST	SPOP	0.8789	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2846:2850	ASSST	SPOP	0.9874	More...
Q10587	Thyrotroph embryonic factor	DEG_SPOP_SBC_1	134:138	ASSST	SPOP	0.9954	More...
Q12967	Ral guanine nucleotide dissociation stimulator	DEG_SPOP_SBC_1	755:759	ASSST	SPOP	0.9656	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	2044:2048	ASSST	SPOP	0.9803	More...
Q15345	Leucine-rich repeat-containing protein 41	DEG_SPOP_SBC_1	367:371	ASSST	SPOP	0.9994	More...
Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A	DEG_SPOP_SBC_1	847:851	ASSST	SPOP	0.9426	More...
Q5SZL2	Centrosomal protein of 85 kDa-like	DEG_SPOP_SBC_1	242:246	ASSST	SPOP	0.9387	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1610:1614	ASSST	SPOP	0.9923	More...
Q6MZP7	Protein lin-54 homolog	DEG_SPOP_SBC_1	369:373	ASSST	SPOP	0.9681	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	590:594	ASSST	SPOP	0.6205	More...
Q8IXK0	Polyhomeotic-like protein 2	DEG_SPOP_SBC_1	755:759	ASSST	SPOP	0.9978	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	144:148	ASSST	SPOP	0.8948	More...
Q9BXK5	Bcl-2-like protein 13	DEG_SPOP_SBC_1	2:6	ASSST	SPOP	0.8664	More...
Q9BZF3	Oxysterol-binding protein-related protein 6	DEG_SPOP_SBC_1	22:26	ASSST	SPOP	0.9974	More...
Q9BZF3	Oxysterol-binding protein-related protein 6	DEG_SPOP_SBC_1	43:47	ASSST	SPOP	0.9981	More...
Q9C091	GREB1-like protein	DEG_SPOP_SBC_1	292:296	ASSST	SPOP	0.9783	More...
Q9H1B7	Probable E3 ubiquitin-protein ligase IRF2BPL	DEG_SPOP_SBC_1	312:316	ASSST	SPOP	0.9428	More...
Q9UMD9	Collagen alpha-1	DEG_SPOP_SBC_1	127:131	ASSST	SPOP	0.9877	More...
Q9Y561	Low-density lipoprotein receptor-related protein 12	DEG_SPOP_SBC_1	693:697	ASSST	SPOP	0.9867	More...
A1A5D9	BICD family-like cargo adapter 2	DEG_SPOP_SBC_1	476:480	ASSST	SPOP	0.8186	More...
P43363	Melanoma-associated antigen 10	DEG_SPOP_SBC_1	38:42	ASSST	SPOP	0.9727	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	760:764	ASSST	SPOP	0.9801	More...
Q6ZRK6	Coiled-coil domain-containing protein 73	DEG_SPOP_SBC_1	921:925	ASSST	SPOP	0.9124	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASSST

Degron related mutations and impact score

Drug responses associated with LRP12 mutations

All proteins holding degron of ASSST