DegronMD

Uniprot ID: P43115

Source protein: Prostaglandin E2 receptor EP3 subtype

Source gene: PTGER3

Class: DEG_SPOP_SBC_1

Location: 368:372

E3 ligase: SPOP

DEGRON score: 0.5018

ASA_SCORE: 87.02

COIL: 0.9212

CONS_SCORE: 0.3629

DSS_SCORE: 0.0915

HELIX: 0.0606

FCONS_SCORE: 1.0889

RIG_SCORE: 0.7305

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R380M	TCGA-56-8504	LUSC	TCGA	ASSST	DEG_SPOP_SBC_1	0.1111
p.R380M	TCGA-BA-A6DA	HNSC	TCGA	ASSST	DEG_SPOP_SBC_1	0.1111
p.R380M	DO44448	HNSC	ICGC	ASSST	DEG_SPOP_SBC_1	0.1111
p.R380M	DO45437	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	0.1111
p.Q377K	TCGA-64-1679	LUAD	TCGA	ASSST	DEG_SPOP_SBC_1	0.1944
p.Q377K	TCGA-DS-A1OC	CESC	TCGA	ASSST	DEG_SPOP_SBC_1	0.1944
p.Q377K	DO6329	CESC	ICGC	ASSST	DEG_SPOP_SBC_1	0.1944
p.Q377K	DO229009	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	0.1944
p.Q377K	DO26200	LUAD	ICGC	ASSST	DEG_SPOP_SBC_1	0.1944
p.Q374L	TCGA-78-7146	LUAD	TCGA	ASSST	DEG_SPOP_SBC_1	0.2778
p.Q374L	DO23717	LUAD	ICGC	ASSST	DEG_SPOP_SBC_1	0.2778
p.Q359K	TCGA-85-7697	LUSC	TCGA	ASSST	DEG_SPOP_SBC_1	0.0833
p.Q359K	DO27053	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	0.0833
p.R361I	TCGA-AH-6549	READ	TCGA	ASSST	DEG_SPOP_SBC_1	0.1389
p.R361I	DO37066	READ	ICGC	ASSST	DEG_SPOP_SBC_1	0.1389
p.A373V	TCGA-B5-A0JU	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	0.3056
p.A373V	DO40819	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	0.3056
p.G373E	TCGA-D3-A51T	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	0.3056
p.G373E	TCGA-EB-A4IS	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	0.3056
p.G373E	DO229462	SKCA	ICGC	ASSST	DEG_SPOP_SBC_1	0.3056
p.G373E	DO47281	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	0.3056
p.G373E	DO47389	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	0.3056
p.E369D	TCGA-DF-A2KN	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	0.6758
p.E369Q	TCGA-E2-A15S	BRCA	TCGA	ASSST	DEG_SPOP_SBC_1	0.6744
p.E370K	TCGA-EB-A41A	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	0.7022
p.E370K	TCGA-EB-A553	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	0.7022
p.E370K	TCGA-EE-A3JA	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	0.7022
p.E370K	TCGA-EE-A3JD	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	0.7022
p.E370K	TCGA-YG-AA3O	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	0.7022
p.E370K	DO220873	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	0.7022
p.E370K	DO220890	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	0.7022
p.E370K	DO220901	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	0.7022
p.E370K	DO222653	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	0.7022
p.E370K	DO229491	SKCA	ICGC	ASSST	DEG_SPOP_SBC_1	0.7022
p.E370K	DO218861	SKCA	ICGC	ASSST	DEG_SPOP_SBC_1	0.7022
p.E370K	DO37429	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	0.7022
p.E370K	DO50299	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	0.7022
p.E370K	DO47329	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	0.7022
p.E370K	DO47625	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	0.7022
p.E370K	DO51299	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	0.7022
p.F371V	TCGA-FF-8043	DLBC	TCGA	ASSST	DEG_SPOP_SBC_1	0.7068
p.F371V	DO222308	DLBC	ICGC	ASSST	DEG_SPOP_SBC_1	0.7068
p.F371Y	TCGA-S5-A6DX	BLCA	TCGA	ASSST	DEG_SPOP_SBC_1	0.7528
p.F371Y	DO51903	BLCA	ICGC	ASSST	DEG_SPOP_SBC_1	0.7528
p.Q377E	DO225160	BRCA	ICGC	ASSST	DEG_SPOP_SBC_1	0.1944
p.Q377E	DO227862	BRCA	ICGC	ASSST	DEG_SPOP_SBC_1	0.1944
p.Q372H	DO50089	COAD	ICGC	ASSST	DEG_SPOP_SBC_1	0.7582
p.E370D	DO233688	GACA	ICGC	ASSST	DEG_SPOP_SBC_1	0.6758
p.Q374H	DO233820	GACA	ICGC	ASSST	DEG_SPOP_SBC_1	0.2778
p.Q372K	DO229025	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	0.6944
p.T382N	DO229036	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	0.0556
p.A373E	DO229045	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	0.3056
p.Q359R	DO231778	LINC	ICGC	ASSST	DEG_SPOP_SBC_1	0.0833
p.G373R	DO231890	LINC	ICGC	ASSST	DEG_SPOP_SBC_1	0.3056
p.A361G	DO45339	LUAD	ICGC	ASSST	DEG_SPOP_SBC_1	0.1389
p.S380F	DO230918	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	0.1111
p.S380F	DO224546	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	0.1111
p.S368Y	DO224563	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	0.712
p.G374W	DO26474	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	0.2778
p.G374W	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.G374W	HCC-15	lung	COSMIC	ASSST	DEG_SPOP_SBC_1	0.2778
p.G374V	DO26474	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	0.2778
p.Q372E	DO27088	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	0.6744
p.Q359L	DO27787	MALY	ICGC	ASSST	DEG_SPOP_SBC_1	0.0833
p.E382K	DO220906	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	0.0556
p.E367K	DO222390	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	0.3056
p.K362I	DO218912	SKCA	ICGC	ASSST	DEG_SPOP_SBC_1	0.1667
p.S378L	DO51246	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	0.1667
p.W370L	DO38380	STAD	ICGC	ASSST	DEG_SPOP_SBC_1	0.7015
p.I377S	DO43041	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	0.1944
p.Q379R	SIDM01096	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.1389
p.Q379R	SIDM01184	Bladder Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.1389
p.Q379R	SIDM00776	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.1389
p.Q379R	SIDM00829	Acute Myeloid Leukemia	GDSC	ASSST	DEG_SPOP_SBC_1	0.1389
p.Q379R	SIDM00148	Breast Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.1389
p.Q379R	SIDM00836	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.1389
p.Q379R	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.1389
p.Q379R	SIDM01726	Ewing's Sarcoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.1389
p.N366S	SIDM00617	Hepatocellular Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00565	Oral Cavity Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00411	Pancreatic Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00781	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00569	Osteosarcoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00466	Ovarian Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM01247	Burkitt's Lymphoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00587	Biliary Tract Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00375	Head and Neck Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00410	Other Blood Cancers	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM01653	Non-Cancerous	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00239	Kidney Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00207	Glioblastoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00591	Oral Cavity Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00279	Gastric Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00531	Pancreatic Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM01551	Gastric Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM01444	Glioblastoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00780	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00500	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM01413	Oral Cavity Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00016	Neuroblastoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM01451	Pancreatic Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366S	SIDM00162	Biliary Tract Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.P375L	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.25
p.P375L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.25
p.P375L	SIDM00875	Breast Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.25
p.Y362H	SIDM00789	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.1667
p.Y362H	ACH-000997	Colon/Colorectal Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	0.1667
p.Y362H	HCT-15	large_intestine	COSMIC	ASSST	DEG_SPOP_SBC_1	0.1667
p.A381E	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.0833
p.A381E	ACH-000757	Lung Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	0.0833
p.A381E	A427	lung	COSMIC	ASSST	DEG_SPOP_SBC_1	0.0833
p.C367Y	SIDM00394	Cervical Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.3056
p.C367Y	SISO	cervix	COSMIC	ASSST	DEG_SPOP_SBC_1	0.3056
p.N366K	SIDM01045	Endometrial Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366K	ACH-000978	Endometrial/Uterine Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	0.2778
p.N366K	EN	endometrium	COSMIC	ASSST	DEG_SPOP_SBC_1	0.2778
p.R380S	SIDM00730	Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.1111
p.R380S	ACH-000610	Lung Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	0.1111
p.R380S	NCI-H2227	lung	COSMIC	ASSST	DEG_SPOP_SBC_1	0.1111
p.V364A	SIDM00217	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.2222
p.V364A	SNU-1040	large_intestine	COSMIC	ASSST	DEG_SPOP_SBC_1	0.2222
p.N365K	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	0.25
p.N365K	ACH-000282	Lung Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	0.25
p.N365K	NCI-H1755	lung	COSMIC	ASSST	DEG_SPOP_SBC_1	0.25
p.S369C	SIDM01691	Chronic Myelogenous Leukemia	GDSC	ASSST	DEG_SPOP_SBC_1	0.643
p.H363P	ACH-000961	Endometrial/Uterine Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	DEG_SPOP_SBC_1	934:938	ASSST	SPOP	0.9942	More...
O00444	Serine/threonine-protein kinase PLK4	DEG_SPOP_SBC_1	296:300	ASSST	SPOP	0.9834	More...
O15085	Rho guanine nucleotide exchange factor 11	DEG_SPOP_SBC_1	652:656	ASSST	SPOP	0.9992	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	695:699	ASSST	SPOP	0.9867	More...
O43719	HIV Tat-specific factor 1	DEG_SPOP_SBC_1	82:86	ASSST	SPOP	0.9934	More...
O95171	Sciellin	DEG_SPOP_SBC_1	173:177	ASSST	SPOP	0.8889	More...
O95935	T-box transcription factor TBX18	DEG_SPOP_SBC_1	369:373	ASSST	SPOP	0.8014	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	3090:3094	ASSST	SPOP	0.9844	More...
P23771	Trans-acting T-cell-specific transcription factor GATA-3	DEG_SPOP_SBC_1	211:215	ASSST	SPOP	0.6066	More...
P37088	Amiloride-sensitive sodium channel subunit alpha	DEG_SPOP_SBC_1	659:663	ASSST	SPOP	0.9733	More...
P43115	Prostaglandin E2 receptor EP3 subtype	DEG_SPOP_SBC_1	368:372	ASSST	SPOP	0.5018	More...
P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	DEG_SPOP_SBC_1	359:363	ASSST	SPOP	0.8789	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2846:2850	ASSST	SPOP	0.9874	More...
Q10587	Thyrotroph embryonic factor	DEG_SPOP_SBC_1	134:138	ASSST	SPOP	0.9954	More...
Q12967	Ral guanine nucleotide dissociation stimulator	DEG_SPOP_SBC_1	755:759	ASSST	SPOP	0.9656	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	2044:2048	ASSST	SPOP	0.9803	More...
Q15345	Leucine-rich repeat-containing protein 41	DEG_SPOP_SBC_1	367:371	ASSST	SPOP	0.9994	More...
Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A	DEG_SPOP_SBC_1	847:851	ASSST	SPOP	0.9426	More...
Q5SZL2	Centrosomal protein of 85 kDa-like	DEG_SPOP_SBC_1	242:246	ASSST	SPOP	0.9387	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1610:1614	ASSST	SPOP	0.9923	More...
Q6MZP7	Protein lin-54 homolog	DEG_SPOP_SBC_1	369:373	ASSST	SPOP	0.9681	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	590:594	ASSST	SPOP	0.6205	More...
Q8IXK0	Polyhomeotic-like protein 2	DEG_SPOP_SBC_1	755:759	ASSST	SPOP	0.9978	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	144:148	ASSST	SPOP	0.8948	More...
Q9BXK5	Bcl-2-like protein 13	DEG_SPOP_SBC_1	2:6	ASSST	SPOP	0.8664	More...
Q9BZF3	Oxysterol-binding protein-related protein 6	DEG_SPOP_SBC_1	22:26	ASSST	SPOP	0.9974	More...
Q9BZF3	Oxysterol-binding protein-related protein 6	DEG_SPOP_SBC_1	43:47	ASSST	SPOP	0.9981	More...
Q9C091	GREB1-like protein	DEG_SPOP_SBC_1	292:296	ASSST	SPOP	0.9783	More...
Q9H1B7	Probable E3 ubiquitin-protein ligase IRF2BPL	DEG_SPOP_SBC_1	312:316	ASSST	SPOP	0.9428	More...
Q9UMD9	Collagen alpha-1	DEG_SPOP_SBC_1	127:131	ASSST	SPOP	0.9877	More...
Q9Y561	Low-density lipoprotein receptor-related protein 12	DEG_SPOP_SBC_1	693:697	ASSST	SPOP	0.9867	More...
A1A5D9	BICD family-like cargo adapter 2	DEG_SPOP_SBC_1	476:480	ASSST	SPOP	0.8186	More...
P43363	Melanoma-associated antigen 10	DEG_SPOP_SBC_1	38:42	ASSST	SPOP	0.9727	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	760:764	ASSST	SPOP	0.9801	More...
Q6ZRK6	Coiled-coil domain-containing protein 73	DEG_SPOP_SBC_1	921:925	ASSST	SPOP	0.9124	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASSST

Degron related mutations and impact score

Drug responses associated with PTGER3 mutations

All proteins holding degron of ASSST