DegronMD - Q6MZP7(LIN54)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S290G	TCGA-DD-AADG	LIHC	TCGA	PGTPSKT	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.1667
p.I287M	TCGA-EW-A1IZ	BRCA	TCGA	PGTPSKT	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.25
p.G279R	TCGA-F1-6177	STAD	TCGA	PGTPSKT	DEG_SCF_FBW7_1	278:284	Mutation altering degron motif	0.6457
p.P380S	TCGA-FI-A2D5	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1389
p.K283N	TCGA-ZF-A9RF	BLCA	TCGA	PGTPSKT	DEG_SCF_FBW7_1	278:284	Mutation altering degron motif	0.5806
p.P374L	DO9924	COAD	ICGC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.S288R	DO231939	LICA	ICGC	PGTPSKT	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.2222
p.P547T	DO228948	LICA	ICGC	LKLYCD	LIG_APCC_ABBA_1	533:538	Mutation rewiring degron network	0.0833
p.T368N	DO229037	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.Y381H	DO227887	PBCA	ICGC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.K541N	DO38803	STAD	ICGC	LKLYCD	LIG_APCC_ABBA_1	533:538	Mutation rewiring degron network	0.25
p.G367D	DO42097	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.2778
p.V383A	DO42023	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0556
p.V379M	DO41871	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1667
p.P291S	DO41331	UCEC	ICGC	PGTPSKT	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.1389
p.T373A	SIDM00845	Burkitt's Lymphoma	GDSC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation altering degron motif	0.7139
p.T373A	SIDM01519	Head and Neck Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation altering degron motif	0.7139
p.S368T	SIDM00845	Burkitt's Lymphoma	GDSC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.S368T	SIDM01519	Head and Neck Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.T280S	SIDM01570	Ovarian Carcinoma	GDSC	PGTPSKT	DEG_SCF_FBW7_1	278:284	Mutation altering degron motif	0.8227
p.T280S	ACH-000324	Ovarian Cancer	CCLE	PGTPSKT	DEG_SCF_FBW7_1	278:284	Mutation altering degron motif	0.8227
p.P374T	SNU-C1	large intestine	COSMIC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.G365E	22RV1	prostate	COSMIC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.2222
p.R285Q	CRO-AP3	NS	COSMIC	PGTPSKT	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.3056
p.P359H	KM12	large intestine	COSMIC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0556

Kaplan plot for LIN54 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LIN54

UniProt ID: Q6MZP7

Entrez ID: 132660

Protein name: Protein lin-54 homolog (CXC domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LIN54 in