DegronMD

Uniprot ID: Q6MZP7

Source protein: Protein lin-54 homolog

Source gene: LIN54

Class: DEG_SCF_FBW7_1

Location: 278:284

E3 ligase: FBXW7

DEGRON score: 0.982

ASA_SCORE: 83.2571

COIL: 0.8404

CONS_SCORE: 0.319

DSS_SCORE: 0.5187

HELIX: 0.0183

FCONS_SCORE: 1.0554

RIG_SCORE: 0.655

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S290G	TCGA-DD-AADG	LIHC	TCGA	PGTPSKT	DEG_SCF_FBW7_1	0.1667
p.I287M	TCGA-EW-A1IZ	BRCA	TCGA	PGTPSKT	DEG_SCF_FBW7_1	0.25
p.G279R	TCGA-F1-6177	STAD	TCGA	PGTPSKT	DEG_SCF_FBW7_1	0.6457
p.K283N	TCGA-ZF-A9RF	BLCA	TCGA	PGTPSKT	DEG_SCF_FBW7_1	0.5806
p.S288R	DO231939	LICA	ICGC	PGTPSKT	DEG_SCF_FBW7_1	0.2222
p.P291S	DO41331	UCEC	ICGC	PGTPSKT	DEG_SCF_FBW7_1	0.1389
p.T280S	SIDM01570	Ovarian Carcinoma	GDSC	PGTPSKT	DEG_SCF_FBW7_1	0.8227
p.T280S	ACH-000324	Ovarian Cancer	CCLE	PGTPSKT	DEG_SCF_FBW7_1	0.8227
p.R285Q	CRO-AP3	NS	COSMIC	PGTPSKT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6MZP7	Protein lin-54 homolog	DEG_SCF_FBW7_1	278:284	PGTPSKT	FBXW7	0.982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons