DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LKLYCD
Uniprot ID:
Q6MZP7
Source protein:
Protein lin-54 homolog
Source gene:
LIN54
Class:
LIG_APCC_ABBA_1
Location:
533:538
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5162
ASA_SCORE:
45.7833
COIL:
0.1633
CONS_SCORE:
0.7588
DSS_SCORE:
0.0002
HELIX:
0.7727
FCONS_SCORE:
1.2614
RIG_SCORE:
0.9803
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P547T
DO228948
LICA
ICGC
LKLYCD
LIG_APCC_ABBA_1
0.0833
p.K541N
DO38803
STAD
ICGC
LKLYCD
LIG_APCC_ABBA_1
0.25
Drug responses associated with LIN54 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LKLYCD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6MZP7
Protein lin-54 homolog
LIG_APCC_ABBA_1
533:538
LKLYCD
APC,CDC20,FZR1
0.5162
More...