DegronMD - P43115(PTGER3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R380M	TCGA-56-8504	LUSC	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1111
p.R380M	TCGA-BA-A6DA	HNSC	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1111
p.R380M	DO44448	HNSC	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1111
p.R380M	DO45437	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1111
p.Q377K	TCGA-64-1679	LUAD	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1944
p.Q377K	TCGA-DS-A1OC	CESC	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1944
p.Q377K	DO6329	CESC	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1944
p.Q377K	DO229009	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1944
p.Q377K	DO26200	LUAD	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1944
p.Q374L	TCGA-78-7146	LUAD	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.Q374L	DO23717	LUAD	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.Q359K	TCGA-85-7697	LUSC	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.Q359K	DO27053	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.R361I	TCGA-AH-6549	READ	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.R361I	DO37066	READ	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.A373V	TCGA-B5-A0JU	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.3056
p.A373V	DO40819	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.3056
p.G373E	TCGA-D3-A51T	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.3056
p.G373E	TCGA-EB-A4IS	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.3056
p.G373E	DO229462	SKCA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.3056
p.G373E	DO47281	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.3056
p.G373E	DO47389	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.3056
p.E369D	TCGA-DF-A2KN	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.6758
p.E369Q	TCGA-E2-A15S	BRCA	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.6744
p.E370K	TCGA-EB-A41A	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7022
p.E370K	TCGA-EB-A553	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7022
p.E370K	TCGA-EE-A3JA	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7022
p.E370K	TCGA-EE-A3JD	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7022
p.E370K	TCGA-YG-AA3O	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7022
p.E370K	DO220873	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7022
p.E370K	DO220890	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7022
p.E370K	DO220901	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7022
p.E370K	DO222653	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7022
p.E370K	DO229491	SKCA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7022
p.E370K	DO218861	SKCA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7022
p.E370K	DO37429	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7022
p.E370K	DO50299	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7022
p.E370K	DO47329	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7022
p.E370K	DO47625	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7022
p.E370K	DO51299	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7022
p.F371V	TCGA-FF-8043	DLBC	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7068
p.F371V	DO222308	DLBC	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7068
p.F371Y	TCGA-S5-A6DX	BLCA	TCGA	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7528
p.F371Y	DO51903	BLCA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7528
p.Q377E	DO225160	BRCA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1944
p.Q377E	DO227862	BRCA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1944
p.Q372H	DO50089	COAD	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7582
p.E370D	DO233688	GACA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.6758
p.Q374H	DO233820	GACA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.Q372K	DO229025	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.6944
p.T382N	DO229036	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0556
p.A373E	DO229045	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.3056
p.Q359R	DO231778	LINC	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.G373R	DO231890	LINC	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.3056
p.A361G	DO45339	LUAD	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.S380F	DO230918	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1111
p.S380F	DO224546	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1111
p.S368Y	DO224563	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.712
p.G374W	DO26474	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.G374W	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.G374W	HCC-15	lung	COSMIC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.G374V	DO26474	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.Q372E	DO27088	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.6744
p.Q359L	DO27787	MALY	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.E382K	DO220906	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0556
p.E367K	DO222390	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.3056
p.K362I	DO218912	SKCA	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1667
p.S378L	DO51246	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1667
p.W370L	DO38380	STAD	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7015
p.I377S	DO43041	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1944
p.Q379R	SIDM01096	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.Q379R	SIDM01184	Bladder Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.Q379R	SIDM00776	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.Q379R	SIDM00829	Acute Myeloid Leukemia	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.Q379R	SIDM00148	Breast Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.Q379R	SIDM00836	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.Q379R	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.Q379R	SIDM01726	Ewing's Sarcoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1389
p.N366S	SIDM00617	Hepatocellular Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00565	Oral Cavity Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00411	Pancreatic Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00781	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00569	Osteosarcoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00466	Ovarian Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM01247	Burkitt's Lymphoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00587	Biliary Tract Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00375	Head and Neck Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00410	Other Blood Cancers	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM01653	Non-Cancerous	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00239	Kidney Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00207	Glioblastoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00591	Oral Cavity Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00279	Gastric Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00531	Pancreatic Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM01551	Gastric Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM01444	Glioblastoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00780	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00500	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM01413	Oral Cavity Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00016	Neuroblastoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM01451	Pancreatic Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366S	SIDM00162	Biliary Tract Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.P375L	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.25
p.P375L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.25
p.P375L	SIDM00875	Breast Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.25
p.Y362H	SIDM00789	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1667
p.Y362H	ACH-000997	Colon/Colorectal Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1667
p.Y362H	HCT-15	large intestine	COSMIC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1667
p.A381E	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.A381E	ACH-000757	Lung Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.A381E	A427	lung	COSMIC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.0833
p.C367Y	SIDM00394	Cervical Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.3056
p.C367Y	SISO	cervix	COSMIC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.3056
p.N366K	SIDM01045	Endometrial Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366K	ACH-000978	Endometrial/Uterine Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.N366K	EN	endometrium	COSMIC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.R380S	SIDM00730	Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1111
p.R380S	ACH-000610	Lung Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1111
p.R380S	NCI-H2227	lung	COSMIC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1111
p.V364A	SIDM00217	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2222
p.V364A	SNU-1040	large intestine	COSMIC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2222
p.N365K	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.25
p.N365K	ACH-000282	Lung Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.25
p.N365K	NCI-H1755	lung	COSMIC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.25
p.S369C	SIDM01691	Chronic Myelogenous Leukemia	GDSC	ASSST	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.643
p.H363P	ACH-000961	Endometrial/Uterine Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTGER3

UniProt ID: P43115

Entrez ID: 5733

Protein name: Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTGER3 in