DegronMD - P60484(PTEN)

GO - Biological processes (BP): adult behavior [GO:0030534]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; brain morphogenesis [GO:0048854]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle tissue development [GO:0048738]; cell migration [GO:0016477]; cell motility [GO:0048870]; cellular response to electrical stimulus [GO:0071257]; cellular response to hypoxia [GO:0071456]; central nervous system development [GO:0007417]; central nervous system myelin maintenance [GO:0032286]; central nervous system neuron axonogenesis [GO:0021955]; dendritic spine morphogenesis [GO:0060997]; dentate gyrus development [GO:0021542]; dephosphorylation [GO:0016311]; endothelial cell migration [GO:0043542]; forebrain morphogenesis [GO:0048853]; heart development [GO:0007507]; inositol phosphate dephosphorylation [GO:0046855]; learning or memory [GO:0007611]; locomotor rhythm [GO:0045475]; locomotory behavior [GO:0007626]; long-term synaptic potentiation [GO:0060291]; male mating behavior [GO:0060179]; maternal behavior [GO:0042711]; multicellular organismal response to stress [GO:0033555]; negative regulation of apoptotic process [GO:0043066]; negative regulation of axonogenesis [GO:0050771]; negative regulation of axon regeneration [GO:0048681]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell aging [GO:0090344]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell size [GO:0045792]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of dendritic spine morphogenesis [GO:0061002]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of keratinocyte migration [GO:0051548]; negative regulation of myelination [GO:0031642]; negative regulation of neuron projection development [GO:0010977]; negative regulation of organ growth [GO:0046621]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of ribosome biogenesis [GO:0090071]; negative regulation of synaptic vesicle clustering [GO:2000808]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; neuron-neuron synaptic transmission [GO:0007270]; phosphatidylinositol 3-kinase signaling [GO:0014065]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of TRAIL-activated apoptotic signaling pathway [GO:1903984]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; postsynaptic density assembly [GO:0097107]; prepulse inhibition [GO:0060134]; presynaptic membrane assembly [GO:0097105]; prostate gland growth [GO:0060736]; protein dephosphorylation [GO:0006470]; protein kinase B signaling [GO:0043491]; protein stabilization [GO:0050821]; regulation of B cell apoptotic process [GO:0002902]; regulation of cellular component size [GO:0032535]; regulation of myeloid cell apoptotic process [GO:0033032]; regulation of neuron projection development [GO:0010975]; regulation of protein kinase B signaling [GO:0051896]; regulation of protein stability [GO:0031647]; regulation of synaptic transmission, GABAergic [GO:0032228]; rhythmic synaptic transmission [GO:0060024]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse maturation [GO:0060074] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E373K	TCGA-G2-A3VY	BLCA	TCGA	VTPDVS	DEG_SCF_FBW7_1	365:370	Mutation rewiring degron network	0.25
p.E373K	TCGA-G2-A3VY	BLCA	TCGA	ASSST	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.0556
p.E373K	DO590	BLCA	ICGC	VTPDVS	DEG_SCF_FBW7_1	365:370	Mutation rewiring degron network	0.25
p.E373K	DO590	BLCA	ICGC	ASSST	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.0556
p.N372D	TCGA-YC-A9TC	BLCA	TCGA	VTPDVS	DEG_SCF_FBW7_1	365:370	Mutation rewiring degron network	0.2778
p.N372D	TCGA-YC-A9TC	BLCA	TCGA	ASSST	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.0833
p.N372D	DO51949	BLCA	ICGC	VTPDVS	DEG_SCF_FBW7_1	365:370	Mutation rewiring degron network	0.2778
p.N372D	DO51949	BLCA	ICGC	ASSST	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.0833
p.S360R	DO228952	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	359:363	Mutation altering degron motif	0.6316
p.P354L	DO221542	PACA	ICGC	ASSST	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTEN

UniProt ID: P60484

Entrez ID: 5728

Protein name: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTEN in