DegronMD

Uniprot ID: P60484

Source protein: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Source gene: PTEN

Class: DEG_SCF_FBW7_1

Location: 365:370

E3 ligase: FBXW7

DEGRON score: 0.9994

ASA_SCORE: 78.7

COIL: 0.9238

CONS_SCORE: 0.2656

DSS_SCORE: 0.7137

HELIX: 0.0367

FCONS_SCORE: 1.1001

RIG_SCORE: 0.6161

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E373K	TCGA-G2-A3VY	BLCA	TCGA	VTPDVS	DEG_SCF_FBW7_1	0.25
p.E373K	DO590	BLCA	ICGC	VTPDVS	DEG_SCF_FBW7_1	0.25
p.N372D	TCGA-YC-A9TC	BLCA	TCGA	VTPDVS	DEG_SCF_FBW7_1	0.2778
p.N372D	DO51949	BLCA	ICGC	VTPDVS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	DEG_SCF_FBW7_1	365:370	VTPDVS	FBXW7	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons