DegronMD: protein-targeted degradation, mutation and drug response to degrons
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CGC
Degron:
LPLYGD
Uniprot ID:
O15085
Source protein:
Rho guanine nucleotide exchange factor 11
Source gene:
ARHGEF11
Class:
LIG_APCC_ABBA_1
Location:
197:202
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6003
ASA_SCORE:
85.7333
COIL:
0.522
CONS_SCORE:
0.3216
DSS_SCORE:
0.6209
HELIX:
0.4622
FCONS_SCORE:
0.8521
RIG_SCORE:
0.7345
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R202W
TCGA-BR-6452
STAD
TCGA
LPLYGD
LIG_APCC_ABBA_1
0.8634
p.R202W
DO219873
SKCA
ICGC
LPLYGD
LIG_APCC_ABBA_1
0.8634
p.R202W
DO38404
STAD
ICGC
LPLYGD
LIG_APCC_ABBA_1
0.8634
p.S207F
DO8898
COAD
ICGC
LPLYGD
LIG_APCC_ABBA_1
0.1944
p.S207F
DO37835
SKCM
ICGC
LPLYGD
LIG_APCC_ABBA_1
0.1944
p.R188Q
DO234462
ESAD
ICGC
LPLYGD
LIG_APCC_ABBA_1
0.0833
p.S201R
DO228974
LICA
ICGC
LPLYGD
LIG_APCC_ABBA_1
0.7427
p.S201R
DO32831
PACA
ICGC
LPLYGD
LIG_APCC_ABBA_1
0.7427
p.R195S
DO229028
LICA
ICGC
LPLYGD
LIG_APCC_ABBA_1
0.2778
p.T203N
DO229024
LICA
ICGC
LPLYGD
LIG_APCC_ABBA_1
0.3056
p.D202G
DO51705
PAAD
ICGC
LPLYGD
LIG_APCC_ABBA_1
0.7198
p.R206S
DO33032
PACA
ICGC
LPLYGD
LIG_APCC_ABBA_1
0.2222
p.L194F
DO219460
SKCM
ICGC
LPLYGD
LIG_APCC_ABBA_1
0.25
p.P196L
DO42280
UCEC
ICGC
LPLYGD
LIG_APCC_ABBA_1
0.3056
p.P207L
DO41331
UCEC
ICGC
LPLYGD
LIG_APCC_ABBA_1
0.1944
p.R195C
SIDM00958
Chronic Myelogenous Leukemia
GDSC
LPLYGD
LIG_APCC_ABBA_1
0.2778
p.R195C
CML-T1
haematopoietic_and_lymphoid_tissue
COSMIC
LPLYGD
LIG_APCC_ABBA_1
0.2778
p.A205T
SIDM01007
T-Lymphoblastic Leukemia
GDSC
LPLYGD
LIG_APCC_ABBA_1
0.25
p.R202Q
SIDM00363
Acute Myeloid Leukemia
GDSC
LPLYGD
LIG_APCC_ABBA_1
0.7329
p.R202Q
P31-FUJ
haematopoietic_and_lymphoid_tissue
COSMIC
LPLYGD
LIG_APCC_ABBA_1
0.7329
p.E210A
ACH-001450
Lymphoma
CCLE
LPLYGD
LIG_APCC_ABBA_1
0.1111
p.E209Q
H513
pleura
COSMIC
LPLYGD
LIG_APCC_ABBA_1
0.1389
p.R211Q
WIL2-NS
haematopoietic_and_lymphoid_tissue
COSMIC
LPLYGD
LIG_APCC_ABBA_1
0.0833
Drug responses associated with ARHGEF11 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPLYGD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15085
Rho guanine nucleotide exchange factor 11
LIG_APCC_ABBA_1
197:202
LPLYGD
APC,CDC20,FZR1
0.6003
More...