DegronMD

Uniprot ID: O15085

Source protein: Rho guanine nucleotide exchange factor 11

Source gene: ARHGEF11

Class: LIG_APCC_ABBA_1

Location: 197:202

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6003

ASA_SCORE: 85.7333

COIL: 0.522

CONS_SCORE: 0.3216

DSS_SCORE: 0.6209

HELIX: 0.4622

FCONS_SCORE: 0.8521

RIG_SCORE: 0.7345

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R202W	TCGA-BR-6452	STAD	TCGA	LPLYGD	LIG_APCC_ABBA_1	0.8634
p.R202W	DO219873	SKCA	ICGC	LPLYGD	LIG_APCC_ABBA_1	0.8634
p.R202W	DO38404	STAD	ICGC	LPLYGD	LIG_APCC_ABBA_1	0.8634
p.S201R	DO228974	LICA	ICGC	LPLYGD	LIG_APCC_ABBA_1	0.7427
p.S201R	DO32831	PACA	ICGC	LPLYGD	LIG_APCC_ABBA_1	0.7427
p.R202Q	SIDM00363	Acute Myeloid Leukemia	GDSC	LPLYGD	LIG_APCC_ABBA_1	0.7329
p.R202Q	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	LPLYGD	LIG_APCC_ABBA_1	0.7329
p.D202G	DO51705	PAAD	ICGC	LPLYGD	LIG_APCC_ABBA_1	0.7198
p.T203N	DO229024	LICA	ICGC	LPLYGD	LIG_APCC_ABBA_1	0.3056
p.P196L	DO42280	UCEC	ICGC	LPLYGD	LIG_APCC_ABBA_1	0.3056
p.R195S	DO229028	LICA	ICGC	LPLYGD	LIG_APCC_ABBA_1	0.2778
p.R195C	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LPLYGD	LIG_APCC_ABBA_1	0.2778
p.R195C	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LPLYGD	LIG_APCC_ABBA_1	0.2778
p.L194F	DO219460	SKCM	ICGC	LPLYGD	LIG_APCC_ABBA_1	0.25
p.A205T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LPLYGD	LIG_APCC_ABBA_1	0.25
p.R206S	DO33032	PACA	ICGC	LPLYGD	LIG_APCC_ABBA_1	0.2222
p.S207F	DO8898	COAD	ICGC	LPLYGD	LIG_APCC_ABBA_1	0.1944
p.S207F	DO37835	SKCM	ICGC	LPLYGD	LIG_APCC_ABBA_1	0.1944
p.P207L	DO41331	UCEC	ICGC	LPLYGD	LIG_APCC_ABBA_1	0.1944
p.E209Q	H513	pleura	COSMIC	LPLYGD	LIG_APCC_ABBA_1	0.1389
p.E210A	ACH-001450	Lymphoma	CCLE	LPLYGD	LIG_APCC_ABBA_1	0.1111
p.R188Q	DO234462	ESAD	ICGC	LPLYGD	LIG_APCC_ABBA_1	0.0833
p.R211Q	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	LPLYGD	LIG_APCC_ABBA_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15085	Rho guanine nucleotide exchange factor 11	LIG_APCC_ABBA_1	197:202	LPLYGD	APC,CDC20,FZR1	0.6003	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons