DegronMD

Uniprot ID: O15085

Source protein: Rho guanine nucleotide exchange factor 11

Source gene: ARHGEF11

Class: DEG_APCC_DBOX_1

Location: 1446:1454

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9741

ASA_SCORE: 84.3333

COIL: 0.2882

CONS_SCORE: 0.4237

DSS_SCORE: 0.4013

HELIX: 0.7072

FCONS_SCORE: 1.2555

RIG_SCORE: 0.7621

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1442R	TCGA-17-Z055	LUAD	TCGA	HRELLKSLG	DEG_APCC_DBOX_1	0.2222
p.R1449H	TCGA-33-4566	LUSC	TCGA	HRELLKSLG	DEG_APCC_DBOX_1	0.8244
p.R1452H	TCGA-AP-A1DK	UCEC	TCGA	HRELLKSLG	DEG_APCC_DBOX_1	0.8244
p.R1452H	TCGA-E2-A155	BRCA	TCGA	HRELLKSLG	DEG_APCC_DBOX_1	0.8244
p.D1445N	TCGA-FI-A2D0	UCEC	TCGA	HRELLKSLG	DEG_APCC_DBOX_1	0.3056
p.R1449C	SIDM00401	Melanoma	GDSC	HRELLKSLG	DEG_APCC_DBOX_1	0.8301
p.R1449C	SIDM00945	Colorectal Carcinoma	GDSC	HRELLKSLG	DEG_APCC_DBOX_1	0.8301
p.R1449C	ACH-000614	Skin Cancer	CCLE	HRELLKSLG	DEG_APCC_DBOX_1	0.8301
p.R1449C	ACH-000895	Colon/Colorectal Cancer	CCLE	HRELLKSLG	DEG_APCC_DBOX_1	0.8301
p.R1449C	ACH-002461	Skin Cancer	CCLE	HRELLKSLG	DEG_APCC_DBOX_1	0.8301
p.R1449C	CL-34	large_intestine	COSMIC	HRELLKSLG	DEG_APCC_DBOX_1	0.8301
p.R1449C	RVH-421	skin	COSMIC	HRELLKSLG	DEG_APCC_DBOX_1	0.8301
p.R1452C	SIDM00950	Pancreatic Carcinoma	GDSC	HRELLKSLG	DEG_APCC_DBOX_1	0.8301
p.R1452C	ACH-000243	Pancreatic Cancer	CCLE	HRELLKSLG	DEG_APCC_DBOX_1	0.8301
p.P1450L	SIDM01019	Acute Myeloid Leukemia	GDSC	HRELLKSLG	DEG_APCC_DBOX_1	0.7582
p.P1450L	ACH-002258	Leukemia	CCLE	HRELLKSLG	DEG_APCC_DBOX_1	0.7582
p.P1450L	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	HRELLKSLG	DEG_APCC_DBOX_1	0.7582
p.V1462A	SIDM01746	Osteosarcoma	GDSC	HRELLKSLG	DEG_APCC_DBOX_1	0.5556
p.V1462A	SIDM01424	B-Lymphoblastic Leukemia	GDSC	HRELLKSLG	DEG_APCC_DBOX_1	0.5556
p.Q1439H	ACH-001061	Colon/Colorectal Cancer	CCLE	HRELLKSLG	DEG_APCC_DBOX_1	0.1389
p.V1464M	OC-314	ovary	COSMIC	HRELLKSLG	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15085	Rho guanine nucleotide exchange factor 11	DEG_APCC_DBOX_1	1446:1454	HRELLKSLG	APC,CDC20,FZR1	0.9741	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons