DegronMD

Uniprot ID: O15085

Source protein: Rho guanine nucleotide exchange factor 11

Source gene: ARHGEF11

Class: DEG_SCF_FBW7_1

Location: 667:672

E3 ligase: FBXW7

DEGRON score: 0.9732

ASA_SCORE: 74.4167

COIL: 0.9175

CONS_SCORE: 0.3704

DSS_SCORE: 0.6696

HELIX: 0.0232

FCONS_SCORE: 0.9431

RIG_SCORE: 0.6297

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R663W	TCGA-A5-A1OF	UCEC	TCGA	PTPPFT	DEG_SCF_FBW7_1	0.6667
p.R663W	TCGA-BR-6452	STAD	TCGA	PTPPFT	DEG_SCF_FBW7_1	0.6667
p.R663W	TCGA-HU-A4GQ	STAD	TCGA	PTPPFT	DEG_SCF_FBW7_1	0.6667
p.R672C	TCGA-DA-A1I7	SKCM	TCGA	PTPPFT	DEG_SCF_FBW7_1	0.8301
p.E677K	DO222739	ESCA	ICGC	PTPPFT	DEG_SCF_FBW7_1	0.1944
p.G676C	DO11585	GBM	ICGC	PTPPFT	DEG_SCF_FBW7_1	0.2222
p.S661F	DO26210	LUAD	ICGC	PTPPFT	DEG_SCF_FBW7_1	0.1667
p.P663L	DO233535	PRAD	ICGC	PTPPFT	DEG_SCF_FBW7_1	0.6667
p.G670E	DO47563	SKCM	ICGC	PTPPFT	DEG_SCF_FBW7_1	0.7199
p.D665G	DO41379	UCEC	ICGC	PTPPFT	DEG_SCF_FBW7_1	0.2778
p.E668D	SIDM00889	Cervical Carcinoma	GDSC	PTPPFT	DEG_SCF_FBW7_1	0.6758
p.E668D	ACH-001333	Cervical Cancer	CCLE	PTPPFT	DEG_SCF_FBW7_1	0.6758
p.E668D	C-33-A	cervix	COSMIC	PTPPFT	DEG_SCF_FBW7_1	0.6758
p.R672H	ACH-001610	Brain Cancer	CCLE	PTPPFT	DEG_SCF_FBW7_1	0.8244
p.D678V	ACH-001624	Brain Cancer	CCLE	PTPPFT	DEG_SCF_FBW7_1	0.1667
p.R677C	NY	bone	COSMIC	PTPPFT	DEG_SCF_FBW7_1	0.1944
p.R677C	RERF-LC-Sq1	lung	COSMIC	PTPPFT	DEG_SCF_FBW7_1	0.1944
p.R677C	SNU-81	large_intestine	COSMIC	PTPPFT	DEG_SCF_FBW7_1	0.1944
p.R677C	JHH-1	liver	COSMIC	PTPPFT	DEG_SCF_FBW7_1	0.1944
p.I680N	ROS-50	haematopoietic_and_lymphoid_tissue	COSMIC	PTPPFT	DEG_SCF_FBW7_1	0.1111
p.E681V	U-118-MG	central_nervous_system	COSMIC	PTPPFT	DEG_SCF_FBW7_1	0.0833
p.T668S	HCC1428	breast	COSMIC	PTPPFT	DEG_SCF_FBW7_1	0.8227

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15085	Rho guanine nucleotide exchange factor 11	DEG_SCF_FBW7_1	667:672	PTPPFT	FBXW7	0.9732	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons